2-Chloro-5-Iodobenzoic Acid CAS 19094-56-5 Empagliflozin Intermediate Assay ≥99.0% (HPLC)

Short Description:

Chemical Name: 2-Chloro-5-Iodobenzoic Acid

CAS: 19094-56-5

Assay: ≥99.0% (HPLC)

Appearance: White or Pale Yellow Crystals

Intermediate of Empagliflozin (CAS: 864070-44-0) for the treatment of type 2 diabetes

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Send email to us

Product Detail

Product Tags

19094-56-5 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 2-Chloro-5-Iodobenzoic Acid (CAS: 19094-56-5) with high quality, intermediates of Empagliflozin (CAS: 864070-44-0). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase 2-Chloro-5-Iodobenzoic Acid, Please contact: alvin@ruifuchem.com

19094-56-5 - Chemical Properties:

Chemical Name	2-Chloro-5-Iodobenzoic Acid
CAS Number	19094-56-5
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C7H4ClIO2
Molecular Weight	282.46
Density	2.077±0.06 g/cm3
Melting Point	161.0~163.0℃(lit.)
Solubility	Soluble in Methanol
Sensitive	Light Sensitive
COA & MSDS	Available
Place of Origin	Shanghai, China
Product Categories	Intermediates of Empagliflozin (CAS: 864070-44-0)
Brand	Ruifu Chemical

19094-56-5 - Specifications:

Item	Specifications	Specifications
Appearance	White or Pale Yellow Crystals	White Crystals
Assay / Analysis Method	≥99.0% (HPLC)	99.91% (HPLC)
Melting Point	161.0~163.0℃	161.7~162.5℃
Loss on Drying	≤0.50%	0.15%
Residue on Ignition	≤0.20%	0.06%
Total Impurities	≤1.00%	0.09%
Heavy Metals	≤20ppm	<20ppm
Residual Solvent	Ethanol	Conforms
Infrared Spectrum	Conforms to Structure	Conforms
Test Standard	Enterprise Standard	Conforms
Usage	Intermediate of Empagliflozin (CAS: 864070-44-0)

19094-56-5 - Synthetic Route:

2-Chloro-5-Iodobenzoic Acid (CAS 19094-56-5) Synthetic Route

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

Advantages:

FAQ:

19094-56-5 - Risk and Safety:

Risk Codes
R25 - Toxic if swallowed
R41 - Risk of serious damage to eyes
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60 - This material and its container must be disposed of as hazardous waste.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs UN 2811 6.1/PG 3
WGK Germany 3
HS Code 2916399090
Hazard Note Irritant
Packing Group III

19094-56-5 - Application:

2-Chloro-5-Iodobenzoic Acid (CAS: 19094-56-5) can be used as a pharmaceutical intermediate in the synthesis of Empagliflozin (CAS: 864070-44-0). Empagliflozin (trade name Jardiance) is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), and causes sugar in the blood to be excreted by the kidneys and eliminated in urine. On August 1, 2014, the Food and Drug Administration (FDA) officially approved the drug for the treatment of type 2 diabetes, to improve and control blood glucose of adults. Empagliflozin is the third SGLT-2 inhibiting drugs approved by FDA. Another two SGLT-2 inhibitor drugs, Canagliflozin and Dapagliflozin, belonging to Johnson Pharmaceuticals, AstraZeneca and Bristol-Myers Squibb respectively, are approved by FDA in November 2013 and January 2014 respectively.