2-Hydroxy-5-Methylpyridine CAS 1003-68-5 Pirfenidone Intermediate Purity ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 2-Hydroxy-5-Methylpyridine (CAS: 1003-68-5) with high quality, intermediate of Pirfenidone (CAS: 53179-13-8) to treat Idiopathic Pulmonary Fibrosis (IPF). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase 2-Hydroxy-5-Methylpyridine, Please contact: alvin@ruifuchem.com
| Chemical Name | 2-Hydroxy-5-Methylpyridine |
| Synonyms | 5-Methyl-2(1H)-Pyridinone; 2-Hydroxy-5-Picoline; 6-Hydroxy-3-Picoline; 5-Methyl-2-Pyridinol |
| CAS Number | 1003-68-5 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C6H7NO |
| Molecular Weight | 109.13 |
| Melting Point | 183.0 to 187.0℃ (lit.) |
| Density | 1.053±0.06 g/cm3 |
| Solubility | Soluble in Methanol |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Product Categories | Pharmaceutical Intermediates |
| Brand | Ruifu Chemical |
| Item | Specifications | Results |
| Appearance | Off-White to Yellow Crystalline Powder | Off-White Crystalline Powder |
| Purity / Analysis Method | ≥99.0% (HPLC) | 99.6% |
| Melting Point | 183.0 to 187.0℃ | 183.0 to 186.0℃ |
| Moisture Content (K.F) | ≤0.50% | 0.10% |
| Residue on Ignition | ≤0.50% | 0.07% |
| Any Single Impurity | ≤0.50% | 0.29% |
| Total Impurities | ≤1.00% | 0.40% |
| Residual Solvents | ||
| n-Butanol | ≤0.30% | Not Detected |
| Ethanol | ≤0.30% | ≤0.20% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
| Application | Intermediate of Pirfenidone (CAS: 53179-13-8) | |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
Hazard Symbols Xn - Harmful
Risk Codes R22 - Harmful if swallowed
R37/38 - Irritating to respiratory system and skin.
R41 - Risk of serious damage to eyes
R36/37/39 -
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37 - Wear suitable gloves.
WGK Germany 3
HS Code 2933 3990.99
2-Hydroxy-5-Methylpyridine (CAS: 1003-68-5) is used as a pharmaceutical intermediate of Pirfenidone (CAS: 53179-13-8). Pirfenidone (PFD) is a novel kind of pyridine ketones which has a broad-spectrum anti-fibrotic effect, being able to prevent and reverse the formation of fibrosis and scar. It entered into market in Shionogi, Japan in 2008 and has been approved by the US food and Drug Administration. It is the first drug which has gone through phase III clinical trials (including repeating, randomized, and placebo-control) which has demonstrates its effectiveness in treating idiopathic pulmonary fibrosis (IPF); moreover, the drug has relative good efficacy in treating some fibrotic diseases such as renal interstitial fibrosis and liver fibrosis.
