2021 Good Quality Aminomalonic Acid Diethyl Ester Hydrochloride - 1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS 143254-82-4 Irinotecan Hydrochloride Intermediate High Purity – Ruifu

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2021 Good Quality Aminomalonic Acid Diethyl Ester Hydrochloride - 1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS 143254-82-4 Irinotecan Hydrochloride Intermediate High Purity – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Supply Irinotecan and Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4

Chemical Name	1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride
CAS Number	143254-82-4
CAT Number	RF-PI243
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C11H20Cl2N2O
Molecular Weight	267.2
Brand	Ruifu Chemical

Item	Specifications
Appearance	White or Light Yellow Powder
Assay	≥98.0% (HPLC)
Loss on Drying	≤1.0%
Heavy Metals	≤20ppm
Test Standard	Enterprise Standard
Usage	Intermediate of Irinotecan Hydrochloride (CAS: 100286-90-6)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride (CAS: 143254-82-4) with high quality. It is an intermediate typically in the synthesis of Irinotecan Hydrochloride (CAS: 100286-90-6), a DNA Topoisomerase I Inhibitor.

lrinotecan hydrochloride, a semi-synthetic, water soluble derivative of the potent anticancer agent camptothecin, was launched in Japan for the treatment of lung, ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibition of topoisomerase I, a cellular enzyme that is involved in maintaining the topographic structure of DNA during the process of translation, transcription, and mitosis. lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38, which is 1000-fold more potent than the parent. Although being much less toxic than camptothecin, a significant number of patients in clinical trials exhibited side effects of leukopenia, diarrhea, nauseahromiting, and alopecia. Combination therapy of irinotecan with another widely used anticancer agent, cisplatin, has been reported to be superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal, breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin’s lymphoma.

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