2021 New Style Ropivacaine Hydrochloride Monohydrate - Luliconazole CAS 187164-19-8 Purity ≥99.0% HPLC Factory API High Quality – Ruifu
2021 New Style Ropivacaine Hydrochloride Monohydrate - Luliconazole CAS 187164-19-8 Purity ≥99.0% HPLC Factory API High Quality – Ruifu Detail:
Supply Luliconazole and Related Intermediates
Luliconazole CAS 187164-19-8
(1-Imidazolyl)acetonitrile CAS 98873-55-3
(S)-2,4-Dichloro-α-(Chloromethyl)benzyl Alcohol CAS 126534-31-4
Chemical Name | Luliconazole |
Synonyms | (2E)-2-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile; NND 502 |
CAS Number | 187164-19-8 |
CAT Number | RF-API110 |
Stock Status | In Stock, Production Scale Up to Tons |
Molecular Formula | C14H9Cl2N3S2 |
Molecular Weight | 354.27 |
Melting Point | 150.0 to 154.0℃ |
Specific Rotation [a]20/D | -48.0° to -53.0° (C=1, DMF) |
Solubility | Insoluble in Water; Soluble in Acetone; Slightly Soluble in Methanol |
Brand | Ruifu Chemical |
Item | Specifications |
Appearance | Off-White to Light Yellow Crystalline Powder |
Identification IR | The infrared spectrum of the sample should correspond to that of the reference standard |
Identification HPLC | The retention time of the major peak of the sample solution should correspond to that of the standard solution as obtained in the test |
Loss on Drying | ≤0.50% |
Residue on Ignition | ≤0.20% |
Heavy Metals (Pb) | ≤20ppm |
Related Substances | |
Any Individual Impurity | ≤0.20% |
Total Impurities | ≤0.50% |
Residual Solvents | |
Methanol | ≤3000ppm |
Acetonitrile | ≤410ppm |
Dichloromethane | ≤600ppm |
N-Hexane | ≤290ppm |
Ethyl Acetate | ≤5000ppm |
Tetrahydrofuran | ≤720ppm |
Methyl tert-Butyl Ether | ≤5000ppm |
N-Heptane | ≤5000ppm |
Triethylamine | ≤320ppm |
Dimethyl Sulfoxide | ≤5000ppm |
Purity / Analysis Method | ≥99.0% (HPLC) (on the dried basis) |
Test Standard | Enterprise Standard |
Usage | Pharmaceutical Intermediates |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer’s requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
Luliconazole (CAS: 187164-19-8) is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole is a kind of analogue of lanoconazole. It can interfere with the fungal cell wall synthesis and fungal growth by decreasing levels of ergosterol via inhibiting lanosterol demethylase activity. Besides being used for the treatment of athlete’s foot, jock itch and ringworm, it has also been developed for onychomycosis (nail fungus) treatment and has now also entered the clinical stage phase III. This product was originally developed by the Japanese pesticide Corporation (NihonNohyaku Co., Ltd.). In November 2013, the FDA has approved a 1% luliconazole cream for entering into market for topical treatment of interdigital athlete’s foot, jock itch and ringworm with the trade name being Luzu and first entered into market in North America. As early as April 2005, luliconazole had been approved to enter into market in Japan under the trade name Lulicon. In January 2010 and June 2012, it was approved for marketing in India and China, respectively.
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By Marcie Green from Mali - 2017.08.28 16:02
Company director has very rich management experience and strict attitude, sales staff are warm and cheerful, technical staff are professional and responsible,so we have no worry about product,a nice manufacturer.
By Teresa from Suriname - 2018.06.26 19:27