4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8 Purity >99.0% (HPLC) Aprepitant Intermediate Factory
Leading manufacturer and supplier
Intermediates of Aprepitant (CAS: 170729-80-3)
4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol CAS 127852-28-2
Please contact: alvin@ruifuchem.com
| Chemical Name | 4-Benzyl-2-Hydroxymorpholin-3-one |
| Synonyms | 4-Benzyl-2-Hydroxy-Morpholin-3-one; 2-Hydroxy-4-(Phenylmethyl)-3-Morpholinone; Aprepitant Impurity 48; Fosaprepitant Impurity 23; Aprepitant Intermediate Ⅱ |
| CAS Number | 287930-73-8 |
| CAT Number | RF2660 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C11H13NO3 |
| Molecular Weight | 207.23 |
| Melting Point | 134.0 to 138.0℃ |
| Boiling Point | 441.7±45.0℃ |
| Density | 1.292±0.06 g/cm3 |
| Solubility in Water | DMSO (Slightly), Methanol (Slightly, Heated) |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Off-White Crystal Powder |
| Purity / Analysis Method | >99.0% (HPLC) |
| Melting Point | 134.0 to 138.0℃ |
| Water (by Karl Fischer) | <0.50% |
| Residue on Ignition | <0.20% |
| Total Impurities | <1.00% |
| Proton NMR Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Aprepitant (CAS: 170729-80-3) Antiemetic Drug |
Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
How to Purchase? Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Russia, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
4-Benzyl-2-Hydroxymorpholin-3-one (CAS: 287930-73-8), is an intermediate of Aprepitant (CAS: 170729-80-3), used as as antiemetic drugs. Aprepitant is a neurokinin-1 (NK-1) receptor antagonist and belongs to the treating agents of vomiting during chemotherapy of cancer. It was first successfully developed by Merck Company (German). In March 2003, the US Food and Drug Administration approved it for being used in the treatment of chemotherapy vomiting. This product has a high selective affinity to human beings while has a low affinity to serotonin, dopamine and glucocorticoid receptor affinity. Aprepitant, when combined with 5-HT3 receptor inhibitors (such as ondansetron hydrochloride) and the corticosteroid dexamethasone, can further alleviate the cisplatin-induced acute and (or) delayed emesis. Applying this drug alone can have some preventive effect.
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