4-(Methylthio)phenylacetic Acid CAS 16188-55-9 Purity >98.0% (GC) (T) Etoricoxib Intermediate

Short Description:

Chemical Name: 4-(Methylthio)phenylacetic Acid

CAS: 16188-55-9

Purity: >98.0% (GC) (T)

Appearance: White to Light Yellow Powder

Intermediate of Etoricoxib (CAS: 202409-33-4)

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16188-55-9 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 4-(Methylthio)phenylacetic Acid (CAS: 16188-55-9) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Intermediates of Etoricoxib (CAS: 202409-33-4):

Etoricoxib API	CAS 202409-33-4
4-(Methylthio)phenylacetic Acid	CAS 16188-55-9
4-(Methylsulfonyl)phenylacetic Acid	CAS 90536-66-6
Methyl 6-Methylnicotinate	CAS 5470-70-2
1-(6-Methylpyridin-3-yl)-2-[4-(Methylthio)phenyl]ethanone	CAS 221615-72-1
1-(6-Methylpyridin-3-yl)-2-[4-(Methylsulfonyl)phenyl]ethanone	CAS 221615-75-4
2-Chloro-1,3-Bis(dimethylamino)trimethinium Hexafluorophosphate	CAS 249561-98-6 ; 291756-76-8

16188-55-9 - Chemical Properties:

Chemical Name	4-(Methylthio)phenylacetic Acid
Synonyms	4-Methylthiophenylacetic Acid; 2-(4-(Methylthio)phenyl)acetic Acid; 2-[4-(Methylsulfanyl)phenyl]acetic Acid; 4-(Methylthio)benzeneacetic Acid
CAS Number	16188-55-9
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C9H10O2S
Molecular Weight	182.24
Melting Point	96.0~99.0℃ (lit.)
Density	1.23±0.10 g/cm3
Storage Condition	2~8℃
Origin of Product	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

16188-55-9 - Specifications:

Item	Specifications
Appearance	White to Light Yellow Powder
Purity / Analysis Method	>98.0% (GC)
Purity / Analysis Method	>98.0% (Neutralization Titration)
Melting Point	96.0~99.0℃
Loss on Drying	<1.00%
Residue on Ignition	<0.50%
Total Impurities	<2.00%
Infrared Spectrum	Conforms to Structure
Test Standard	Enterprise Standard
Usage	Intermediate of Etoricoxib (CAS: 202409-33-4)

16188-55-9 - Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

16188-55-9 - Advantages:

16188-55-9 - FAQ:

16188-55-9 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany 3
HS Code 2930909099

16188-55-9 - Application:

4-(Methylthio)phenylacetic Acid (CAS: 16188-55-9) is the key intermediate for the preparation of Etoricoxib (CAS: 202409-33-4). Etoricoxib is a kind of highly selective cyclooxygenase-2 (COX-2) inhibitors developed by the Merck company with the chemical name being 5-chloro-6'-methyl-3-4-(methanesulfonamide) phenyl]-2, 3'-bipyridine. Etoricoxib has a unique chemical structure that is methylsulfonyl group. The introduction of this group can not only increase the selectivity for COX-2 drugs, but also does not produce sulfa drugs and cross-allergic reactions. Etoricoxib is widely used in treatment of osteoarthritis (OA), rheumatoid arthritis, ankylosing spondylitis, chronic low back pain, acute gouty arthritis, primary dysmenorrhea and postoperative pain, and other diseases.