7-Hydroxy-3,4-Dihydro-2(1H)-Quinolinone CAS 22246-18-0 Purity ≥99.0% (HPLC) Aripiprazole Intermediate Factory
Shanghai Ruifu Chemical Co., Ltd. is the leading supplier of 7-Hydroxy-3,4-Dihydro-2(1H)-Quinolinone (CAS: 22246-18-0) with high quality, intermediate of Aripiprazole (CAS: 129722-12-9).
Purchase intermediates of Aripiprazole, please contact us by e-mail: alvin@ruifuchem.com
| Chemical Name | 7-Hydroxy-3,4-Dihydro-2(1H)-Quinolinone |
| Synonyms | 3,4-Dihydro-7-Hydroxy-2(1H)-Quinolinone; 7-Hydroxy-3,4-Dihydrocarbostyril; 7-Hydroxy-2-oxo-1,2,3,4-Tetrahydroquinoline; 7-Hydroxycarbostyril; Aripiprazole Impurity 5; Aripiprazole EP Impurity A |
| CAS Number | 22246-18-0 |
| Stock Status | In Stock, Production Capacity 60MT/Year |
| Molecular Formula | C9H9NO2 |
| Molecular Weight | 163.18 |
| Melting Point | 233.0~239.0℃ |
| Solubility | Soluble in Methanol |
| Density | 1.282±0.060 g/cm3 |
| COA & MSDS | Available |
| Bulk Order Sample | Available |
| Origin of Product | Shanghai, China |
| Product Categories | Pharmaceutical Intermediates |
| Brand | Ruifu Chemical |
| Item | Specifications | Results |
| Appearance | Pale Yellow or Almost White Powder | White Powder |
| Identification (HPLC) | Retention Time of the Sample Conforms to that of the Reference Standard |
Conforms |
| Melting Point | 233.0~239.0℃ | 237.6℃ |
| Purity / Analysis Method | ≥99.0% (HPLC) | 99.6% |
| Other Single Impurity | ≤0.30% | 0.14% |
| Total Impurities | ≤1.00% | 0.40% |
| Loss on Drying | ≤1.00% | 0.14% |
| Residue on lgnition | ≤0.50% | 0.30% |
| Assay | ≥99.0% | 99.8% |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Fluorinated bottle, aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry and well-ventilated warehouse away from incompatible substances. Keep away from direct sunlight; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.
| HS Code | 2933 4900.90 |
7-Hydroxy-3,4-Dihydro-2(1H)-Quinolinone (CAS: 22246-18-0) is used as the intermediate of Aripiprazole (CAS: 129722-12-9).
Aripiprazole is a new kind of highly lipid soluble quinoline derivatives, its pharmacological effects characteristic is that it is not only the postsynaptic dopamine D 2 receptor antagonist, but also the presynaptic dopamine D 2 receptor agonist, it can also excite D 1, D 3, D 4 receptors; Aripiprazole has dual effect of partial activation or receptor antagonistic on 5-HT 1A receptor; it has a completely antagonistic action on the 5-HT 2A receptor. This feature is different from the first generation, and atypical antipsychotics which belong to the second-generation antipsychotic drugs, and therefore it is called dopamine system stabilizer or third generation antipsychotic.
Since it is sold in the market, Aripiprazole is mainly used in clinical schizophrenia, treatment of affective disorders and other psychiatric disorders. According to the literature, aripiprazole has significant effects on schizophrenia positive and negative symptoms and anxiety, depression, cognitive function, while higher safety. Aripiprazole was also reported that the drug can also treat other mental disorders, such as mood disorders manic episodes, senile dementia associated with mental disorders, anxiety disorders, children's behavioral disorders, depression.
