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8 Year Exporter ECPPA - Boc-Leu-OH.H2O CAS 13139-15-6 Purity ≥98.5% (HPLC) – Ruifu Featured Image
  • 8 Year Exporter ECPPA - Boc-Leu-OH.H2O CAS 13139-15-6 Purity ≥98.5% (HPLC) – Ruifu

8 Year Exporter ECPPA - Boc-Leu-OH.H2O CAS 13139-15-6 Purity ≥98.5% (HPLC) – Ruifu

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8 Year Exporter ECPPA - Boc-Leu-OH.H2O CAS 13139-15-6 Purity ≥98.5% (HPLC) – Ruifu Detail:

Manufacturer Supply; High Purity and Competitive Price 
Shanghai Ruifu Chemical Co., Ltd. Commercial Supply Carfilzomib (CAS: 868540-17-4) Related Intermediates:
Boc-L-Leucine.H2O;Boc-L-Leucine monohydrate; CAS: 13139-15-6
Boc-L-Homophenylalanine; Boc-L-HomePhe-OH; CAS: 100564-78-1
2-Bromopropene CAS: 557-93-7

Chemical Name Boc-Leu-OH.H2O
Synonyms Boc-L-Leucine.H2O; Boc-L-Leu-OH; Boc-L-Leucine Monohydrate
CAS Number 13139-15-6
CAT Number RF-PI115
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C11H21NO4
Molecular Weight 231.29
Density  1.061±0.06 g/cm3
Boiling Point 356℃ at 760 mmHg
Brand Ruifu Chemical
Item Specifications
Appearance White or Off-White Crystalline Powder
Specific Rotation -23.0° ~ -26.0° (C=1, AcOH)
Purity / Analysis Method ≥98.0% (HPLC)
Melting Point 82.0 ~ 90.0℃
Test Standard Enterprise Standard
Usage Pharmaceutical Intermediates; Organic Synthesis

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

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Shanghai Ruifu Chemical Co., Ltd. Commercial Supply Carfilzomib (CAS: 868540-17-4) Related Intermediates:
Boc-L-Leucine.H2O;Boc-L-Leucine monohydrate; CAS: 13139-15-6
Boc-L-Homophenylalanine; Boc-L-HomePhe-OH; CAS: 100564-78-1
2-Bromopropene CAS: 557-93-7

Carfilzomib is an irreversible proteasome inhibitor and antineoplastic agent.The mechanism of action of carfilzomib is as a Proteasome Inhibitor, Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.
Carfilzomib is used in treatment of refractory multiple myeloma. Carfilzomib is associated with a low rate of serum enzyme elevations during treatment and has been implicated to rare instances of clinically apparent, acute liver injury some of which have been fatal.
Carfilzomib is a second-generation, irreversible, peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases. It can induce cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors

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