Afatinib Dimaleate Intermediate CAS 314771-76-1 Purity >99.0% (HPLC) Factory

Short Description:

Chemical Name: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Purity: >99.0% (HPLC)

Appearance: Light Yellow to Yellow Powder

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

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Product Detail

Product Tags

Description:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine CAS 314771-88-5

Chemical Properties:

Chemical Name	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Synonyms	N4-(3-Chloro-4-Fluorophenyl)-7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine; Afatinib Impurity B; Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl; Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
CAS Number	314771-76-1
CAT Number	RF-PI2028
Stock Status	In Stock, Production Capacity 100MT/Year
Molecular Formula	C18H16ClFN4O2
Molecular Weight	374.8
Boiling Point	559.0±50.0℃
Density	1.473±0.060 g/cm3
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	Light Yellow to Yellow Powder
Identification	The Retention Time of Principal Peak in HPLC Should Correspond to the Standard
Purity / Analysis Method	>99.0% (HPLC)
Loss on Drying	<0.50%
Residue on Ignition	<0.20%
Single Impurity	<0.50%
Total Impurities	<1.00%
Heavy Metals (as Pb)	≤20ppm
Test Standard	Enterprise Standard
Usage	Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

FAQ:

Application:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) is an intermediate of Afatinib Dimaleate (CAS: 850140-73-7). Afatinib is the second-generation potent and irreversible dual inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinase, developed by Boehringer Ingelheim, Germany. It is capable of irreversibly inhibiting the activity of the tyrosine kinase by undergoing the Michael reaction with the thiol group of cysteine at position 797 of the EGFR. Function: 1. Like Lapatinib and Neratinib, Afatinib is a protein kinase inhibitor that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. 2. Afatinib is not only active against EGFR mutations targeted by first generation TKIs like erlotinib or gefitinib, but also against mutations such as T790M which are not sensitive to these standard therapies. Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers. 3. Afatinib is a drug for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC). It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2).