Apixaban Intermediate CAS 503614-91-3 Purity ≥99.0% (HPLC) Factory High Quality

Short Description:

Chemical Name: Apixaban Intermediate

CAS: 503614-91-3

Purity: ≥99.0% (HPLC)

Appearance: Off-White to Pale Yellow Powder

Intermediate of Apixaban (CAS: 503612-47-3)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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503614-91-3 - Description:

Ruifu Chemical is the leading manufacturer of Apixaban Intermediate (CAS: 503614-91-3) with high quality.
Ruifu Chemical has been supplying pharmaceutical intermediates and APIs (Active Pharmaceutical Ingredients) more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Apixaban Intermediates, please contact us by e-mail: alvin@ruifuchem.com

503614-91-3 - Chemical Properties:

Chemical Name	1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
Synonyms	Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate; Apixaban Intermediate; Apixaban V; Apixaban Impurity 9; Apixaban Ethyl Ester Impurity; Apixaban Ethyl Ester
Stock Status	In Stock, Commercial Production
CAS Number	503614-91-3
Molecular Formula	C27H28N4O5
Molecular Weight	488.54 g/mol
Melting Point	175.0~180.0℃
Density	1.34
Storage	2-8℃ Refrigerator
Shipping Conditions	Ambient
COA & MSDS	Available
Origin of Product	Shanghai, China
Product Categories	Apixaban Intermediates
Reference Standard	In-house Standard
Brand	Ruifu Chemical

503614-91-3 - Specifications:

Items	Specifications	Results
Appearance	Off-White to Pale Yellow Powder	Off-White Powder
Identification	The retention time of the major peak of the sample solution corresponds to that of the standard solution	Complies
Water by Karl Fischer	≤0.50%	0.11%
Related Substances
Individual Impurities	≤0.30%	0.13%
Total Impurities	≤1.00%	0.27%
Purity / Analysis Method	≥99.0% (HPLC)	99.73%
1H NMR Spectrum	Conforms to Structure	Conforms
Conclusion	The product has been tested and complies with the given specifications

503614-91-3 - Package/Storage/Shipping:

Package: Fluorinated bottle, aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

503614-91-3 - Application:

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester (CAS: 503614-91-3) is an intermediate for the preparation of apixaban. apixaban is an antithrombotic drug. It is a direct inhibitor of factor Xa jointly developed by Bristol-Myers Squibb and Pfizer. It was approved for listing in the European Union in March 2011, and F DA approved the drug for listing in the United States in December 2012.

Apixaban Intermediates:

Apixaban	CAS: 503612-47-3
Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate	CAS: 27143-07-3
1-(4-Aminophenyl)-3-Morpholino-5,6-Dihydropyridin-2(1H)-one	CAS: 1267610-26-3
3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-one	CAS: 503615-03-0
3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-one	CAS 545445-44-1
1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester	CAS: 503614-91-3