Bis(2-Chloroethyl)amine Hydrochloride CAS 821-48-7 Purity >99.0% (HPLC)

Short Description:

Bis(2-Chloroethyl)amine Hydrochloride

CAS: 821-48-7

Purity: >99.0% (HPLC)

Appearance: White Crystalline Powder

Intermediate of Ketoconazole and Itraconazole

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

821-48-7 - Description:

Ruifu Chemical is the leading manufacturer of Bis(2-Chloroethyl)amine Hydrochloride (CAS: 821-48-7) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Bis(2-Chloroethyl)amine Hydrochloride, Please contact: alvin@ruifuchem.com

821-48-7 - Chemical Properties:

Chemical Name	Bis(2-Chloroethyl)amine Hydrochloride
Synonyms	Bis(2-Chloroethyl)amine HCl; 2,2'-Dichlorodiethylamine Hydrochloride; 2-Chloro-N-(2-Chloroethyl)ethylamine Hydrochloride
Stock Status	In Stock, Commercial Production
CAS Number	821-48-7
Molecular Formula	C4H9Cl2N·HCl
Molecular Weight	178.48 g/mol
Melting Point	210.0~216.0℃(lit.)
Density	1.125
Sensitive	Hygroscopic
Water Solubility	Partly Miscible in Water
COA & MSDS	Available
Sample	Available
Origin of Product	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

821-48-7 - Specifications:

Items	Inspection Standards	Results
Appearance	White Crystalline Powder	White Crystalline Powder
Melting Point	210.0~216.0℃	213.0~215.0℃
Loss on Drying	<0.50%	0.18%
Total Related Impurities	<1.00%	0.25%
Purity / Analysis Method	>99.0% (HPLC)	99.75%
Infrared Spectrum	Consistent with Structure	Complies
1H NMR Spectrum	Consistent with Structure	Complies
Conclusion	The product has been tested and complies with the given specifications
Application	Intermediate of Ketoconazole, Itraconazole

821-48-7 - Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture. Incompatible with oxidizing agents and bases.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

821-48-7 - Test Method:

Column model: AC-10 30m-0.53mm-1.0um
Methods: Area normalization method
Vaporization temperature: 230℃
Detection temperature: 250℃ FID
Column temperature: 80℃ for 2min, 10℃/min to 200℃ for 3min, 10℃/min to 200℃ for 5min
Split ratio: 40:1
Injection volume: 0.2μL

821-48-7 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

821-48-7 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

821-48-7 - Safety Information:

Hazard Symbols Xi - Irritant
Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs 2811
WGK Germany 3
RTECS IA1225000
TSCA Yes
HS Code 2921199090
Hazard Class 8
Packing Group III
Toxicity LD50 orally in Rabbit: 1150 mg/kg

821-48-7 - Application:

Bis(2-Chloroethyl)amine Hydrochloride (CAS: 821-48-7) is used as an organic synthesis intermediate, pharmaceutical intermediate. Intermediate of Ketoconazole (CAS: 65277-42-1), Itraconazole (CAS: 84625-61-6) and Terconazole (CAS: 67915-31-5). Ketoconazole is a broad-spectrum antifungal imidazole. Itraconazole is an artificially synthetic clotrimazole, being a broad-spectrum synthetic antifungal agent. Its antimicrobial spectrum and antimicrobial mechanism is similar to clotrimazole, but has strong antibacterial activity against Aspergillus. Terconazole is an antifungal agent somewhat more potent than clotrimazole and useful in the topical treatment of vaginal dermatophytosis and candidiasis.

821-48-7 - Production Method:

Bis(2-Chloroethyl)amine Hydrochloride (CAS: 821-48-7) is obtained by the reaction of diethanolamine and thionyl chloride. Dissolve thionyl chloride in chloroform, and drop a mixture of diethanolamine and chloroform below 0℃. Control the droplet acceleration to maintain the temperature at -4-6℃. After adding, keep the temperature and stir for 30min. Stir at room temperature for 1h, heat to 60-65℃, after all crystallization is precipitated, add anhydrous ethanol, heat and reflux to dissolve all. Pour out while hot, cool naturally, and precipitate crystals. Filter the next day and wash twice with chloroform or absolute ethanol. Dry to obtain a finished product with a 76% yield.

821-48-7 - Safety Profile:

A poison by inhalation,intraperitoneal, intramuscular, and subcutaneous routes.An experimental teratogen. Human mutation datareported. When heated to decomposition it emits toxicfumes of NH3, NOx, and Cl-.