Posaconazole Intermediate CAS 175712-02-4 Purity >99.0% (GC) Factory

Short Description:

Chemical Name: Posaconazole Intermediate 

CAS: 175712-02-4

Purity: >99.0% (GC)

Appearance: White Solid

Intermediate of Posaconazole (CAS: 171228-49-2)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Posaconazole Intermediate (CAS: 175712-02-4) with high quality. Ruifu Chemical supplys a series of pharmaceutical intermediates. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Posaconazole Intermediate, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name Posaconazole Intermediate 
Synonyms Posaconazole Impurity 21; (5R-Cis)- P-Chlorobenzenesulfonic Acid 5; [(3S,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetrahydrofuran-3-yl]methyl 4-Chlorobenzenesulfonate; (3S-cis)-4-Chlorobenzenesulfonic Acid [5-(2,4-Difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-Furanyl]methyl Ester
Stock Status In Stock 
CAS Number 175712-02-4
Molecular Formula C20H18ClF2N3O4S
Molecular Weight 469.89 g/mol
Density 1.49±0.10 g/cm3 
Storage Temp.  Cool & Dry Place (2~8℃) 
COA & MSDS Available
Category   Pharmaceutical Intermediates  
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance White Solid White Solid 
Water by Karl Fischer  <0.50% 0.20%
Purity / Analysis Method >99.0% (GC)  99.3% 
1 H NMR Spectrum Consistent with Structure Complies         
LCMS Consistent with Structure Complies         
Conclusion The product has been tested & complies with the specifications

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Application:

Posaconazole Intermediate (CAS: 175712-02-4) is an intermediate of Posaconazole (CAS: 171228-49-2). Posaconazole, launched in the UK, is the newest member of the azole class of antifungal agents to reach the market. It is indicated for the treatment and prophylaxis of a range of invasive fungal infections, including aspergillosis,fusariosis, chromoblastomycosis, mycetoma, and coccidiomycosis in patients who are refractory to, or intolerant of, standard therapy with amphotericin B and/or itraconazole. In the US, it is approved for the prophylaxis of invasive Aspergillus and Candida infections in patients 13 years of age who are at high risk of developing these infections due to being severely immunocompromised. Additionally, it is approved for the treatment of oropharyngeal candidiasis. Posaconazole has an expanded spectrum of activity over other members of the azole antifungals. In addition to potent activity against refractory cases of aspergillosis and fluconazole-resistant Candida, it demonstrates activity against Zygomycetes. 

Biochem/Physiol Actions Posaconazole is a highly potent broadspectrum antifungal agent against the yeast infection caused especially by Candida sp. It blocks the growth of fungi by inhibiting the enzyme lanosterol 14α-demethylase (CYP51). In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole exhibits antichagasic effects against different strains of Trypanosoma cruzi causing Chagas disease.

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