1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-one CAS 27387-31-1 Ondansetron HCl Dihydrate Intermediate Purity >99.0% (HPLC)

1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-one (CAS: 27387-31-1) is used as an intermediate of Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9). The United Kingdom Glaxo company development, 1990 in France, the United Kingdom market. The product is a highly selective serotonin (5-HT3) receptor antagonist, can inhibit Nausea caused by chemotherapy and radiotherapy Vomit, with high strength and high selectivity, can control the small intestine and CTZ receptors caused by the stimulation of Vomit. It is suitable for the treatment of Nausea Vomit caused by chemotherapy and radiotherapy, and can also be used for the prevention and treatment of Nausea Vomit caused after surgery. 

Ondansetron, granisetron and dolasetron are three antiemetic drugs commonly used in clinic, ondansetron is a potent, selective and reversible 5-hydroxytryptamine (5-HT3) receptor blocker for Alpha 1, Alpha 2, beta 1, Beta 2 adrenergic receptors and histamine H1, h2 receptor has little effect, and has no antagonistic effect on H receptor, central and peripheral dopaminergic receptors, and can inhibit Nausea and Vomit caused by chemotherapy and radiotherapy. Compared with metoclopramide, The antiemetic effect was strong and there was no extrapyramidal reaction. Cisplatin, cyclophosphamide, doxorubicin caused by Vomit can produce rapid and strong anti-nausea effect. Suitable for the treatment of cytotoxic drugs caused by chemotherapy and radiation therapy Nausea Vomit, but also the prevention and treatment of Nausea Vomit caused by surgery. ondansetron acts as a transfer station between activated visceral afferent nerves in the gastrointestinal tract and Vomit of the centers in the spinal cord, causing abdominal and diaphragmatic movements. Chemotherapy drugs and radiation therapy can cause the release of 5-HT in the small intestine, and the Vomit reflex is caused by the stimulation of the vagus nerve through the 5-HT3 receptor. This product blocks the occurrence of this reflex, while blocking Vomit triggered by central action. The mechanism of action was unknown for Nausea Vomit after surgery. Ondansetron combined with dexamethasone can enhance the antiemetic effect.