Cyproheptadine Hydrochloride Sesquihydrate CAS 41354-29-4 Assay 98.5~100.5%

Short Description:

Cyproheptadine Hydrochloride Sesquihydrate

CAS: 41354-29-4

Assay: 98.5~100.5% (Calculated on the Anhydrous Basis)

Appearance: White to Light Yellow Crystalline Powder

Contact: Dr. Alvin Huang

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Description:

Ruifu Chemical is the leading manufacturer of Cyproheptadine Hydrochloride Sesquihydrate (CAS: 41354-29-4) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Cyproheptadine Hydrochloride Sesquihydrate, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	Cyproheptadine Hydrochloride Sesquihydrate
Synonyms	4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride Sesquihydrate
Stock Status	In Stock, Commercial Production
CAS Number	41354-29-4
Related CAS	969-33-5 & 129-03-3
Molecular Formula	C21H21N·HCl·11/2H2O
Molecular Weight	350.88 g/mol
Melting Point	165℃(dec.)(lit.)
Water Solubility	Practically Insoluble in Water
Solubility	Very Soluble in Methanol. Soluble in Chloroform. Slightly Soluble in Ethanol. Insoluble in Ether
COA & MSDS	Available
Sample	Available
Origin	Shanghai, China
Brand	Ruifu Chemical

Specifications:

Items	Inspection Standards	Results
Appearance	White to Light Yellow Crystalline Powder	Complies
Identification	A. Infrared Spectrum Should Conform	Complies
Identification	B. Should Conform	Complies
Chromatographic Purity	Should Conform	Complies
Assay	98.5~100.5% (Calculated on the Anhydrous Basis)	99.62%
Water by Karl Fischer	7.0~9.0%	8.2%
Residue on Ignition	≤0.10%	0.08%
Acidity	≤0.15ml	≤0.13ml
Heavy Metals	≤10ppm	8ppm
Infrared Spectrum	Conforms to Structure	Complies
Conclusion	This product by inspection accords with the standard of USP35
Shelf Life	2 Years if Stored Properly

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

41354-29-4 - USP35 Standard:

Cyproheptadine Hydrochloride
C21H21N·HCl·1½H2O 350.88
Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride, sesquihydrate.
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride sesquihydrate [41354-29-4].
Anhydrous 323.87 [969-33-5].
Cyproheptadine Hydrochloride contains not less than 98.5 percent and not more than 100.5 percent of C21H21N·HCl, calculated on the anhydrous basis.
Packaging and storage- Preserve in well-closed containers.
USP Reference standards <11>-
USP Cyproheptadine Hydrochloride RS
Identification-
A: Infrared Absorption <197K>.
B: Ultraviolet Absorption <197U>-
Solution: 16 µg per mL.
Medium: alcohol.
Absorptivities at 286 nm do not differ by more than 3.0%.
C: Dissolve 100 mg of Cyproheptadine Hydrochloride in 10 mL of methanol. Place 1 drop of the solution on a filter paper, dry, and view under short-wavelength UV light: a bright blue fluorescence is observed.
Acidity- Dissolve 1.0 g of Cyproheptadine Hydrochloride in 25 mL of methanol, add methyl red TS, and titrate with 0.10 N sodium hydroxide: not more than 0.15 mL is required (0.05% as HCl).
Water, Method I <921>: between 7.0% and 9.0%.
Residue on ignition <281>: not more than 0.1%.
Heavy metals, Method II <231>: 0.003%.
Assay-Dissolve about 650 mg of Cyproheptadine Hydrochloride, accurately weighed, in 50 mL of glacial acetic acid, heating to dissolve. Cool, add 10 mL of mercuric acetate TS, 0.5 mL of acetic anhydride, and 1 drop of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 32.39 mg of C21H21N·HCl.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

41354-29-4 - Risk and Safety:

Hazard Symbols Xn - Harmful
Risk Codes
R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
UN IDs UN 2811 6.1/PG 3
WGK Germany 3
RTECS TM7050000
HS Code 2933399011
Hazard Class 6.1
Packing Group III
Toxicity LD50 orally in mice: 74.2 mg/kg (Loux)

41354-29-4 - Application:

Cyproheptadine Hydrochloride Sesquihydrate (CAS: 41354-29-4) is a kind of pipecolic antihistamines,it can compete with histamine released from the organization for H1 receptor on effector cells, thereby it can prevent the onset of an allergic reaction, and release histamine-induced spasm and congestion effects, this product has a strong H1 receptor antagonism, its anti-histamine effect is stronger than chlorpheniramine, promethazine . There are mild to moderate anti-serotonin effects and anticholinergic effects. In addition, there is a stimulate appetite effect, and weight gains after a certain time.
Clinically Cyproheptadine hydrochloride sesquihydrate is mainly used for acute and chronic urticaria (especially cold urticaria), papular urticaria, angioedema, allergic eczema, contact dermatitis, food allergy, drug allergy, allergic rhinitis, hay fever, allergic conjunctivitis, insect sting allergy and migraine. It has a certain therapeutic effect on bronchial asthma. It can still be used for the adjuvant treatment of Cushing's syndrome and acromegaly. It can also be used as an appetite enhancer for neurotic phobias. There are reports of treatment of acanthosis nigricans and prevention of necrotizing pyoderma.
Function and Application of Cyproheptadine Hydrochloride Sesquihydrate (CAS: 41354-29-4)
1. Cyproheptadine Hydrochloride for the treatment of urticaria, itchy skin and allergic rhinitis.
2. Cyproheptadine Hydrochloride is a new drug in the anticoagulant and anti-allergic class. It can be used for allergic reactions such as urticaria, eczema, allergic and contact dermatitis and pruritus. Urticaria, eczema, allergic and contact dermatitis, pruritus, rhinitis, migraine and bronchial asthma. Also used for Cushing's disease and acromegaly.
3. Cyproheptadine Hydrochloride is an anti-allergic drug that counteracts the action of histamine in the body on blood vessels and bronchial smooth muscle, thus eliminating allergic symptoms. Cyproheptadine hydrochloride is used for allergic reactions such as urticaria, eczema, allergic and contact dermatitis and itchy skin.