China New Product 2-Chloropropionic Acid Ethyl Ester - Rivaroxaban Intermediate CAS 446292-07-5 Purity ≥98.0% (HPLC) – Ruifu

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China New Product 2-Chloropropionic Acid Ethyl Ester - Rivaroxaban Intermediate CAS 446292-07-5 Purity ≥98.0% (HPLC) – Ruifu Detail:

Manufacturer Supply; High Purity and Competitive Price
Commercial Supply Rivaroxaban (CAS: 366789-02-8) Related Intermediates:
(S)-(+)-Glycidyl Phthalimide CAS: 161596-47-0
4-(4-Aminophenyl)morpholin-3-one CAS: 438056-69-0
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione CAS: 446292-07-5
5-Chlorothiophene-2-carboxylic acid CAS: 24065-33-6
Rivaroxaban CAS: 366789-02-8

Chemical Name 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione
Synonyms Rivaroxaban Intermediates
CAS Number 446292-07-5
CAT Number RF-PI130
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C21H21N3O5
Molecular Weight 395.41
Brand Ruifu Chemical
Item Specifications
Appearance White Powder
Purity / Analysis Method ≥98.0% (HPLC)
Melting Point 210.0℃~215.0℃
Any Individual Impurity ≤1.0%
Loss on Drying ≤0.50%
Residue on Ignition ≤0.10%
Test Standard Enterprise Standard
Usage Rivaroxaban (CAS: 366789-02-8) Intermediates 

Rivaroxaban Intermediates CAS 446292-07-5 Synthesis Route

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

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Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione (CAS: 446292-07-5) with high quality. It is an intermediate typically in the synthesis of Rivaroxaban (CAS: 366789-02-8). 

Rivaroxaban (Xarelto; CAS: 366789-02-8) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. Rivaroxaban also inhibits prothrombinase activity with IC50 of 2.1 nM. Rivaroxaban also shows a similar affinity to purified human and rabbit FXa (IC50 0.7 nM and 0.8 nM, respectively), but a lesser potency against purified rat FXa (IC50 3.4 nM). Endogenous human and rabbit FXa in plasma is inhibited to a similar extent by Rivaroxaban (IC50 21 nM and 21 nM, respectively), while 14-fold higher concentrations are required in rat plasma (IC50 290 nM). Rivaroxaban exhibits high permeability and polarized transport across Caco-2 cells as a substrate of the P-gp, but exhibits no inhibitory effect on P-gp-mediated drug transport up to concentrations of 100 μM in vitro. 


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China New Product 2-Chloropropionic Acid Ethyl Ester - Rivaroxaban Intermediate CAS 446292-07-5 Purity ≥98.0% (HPLC)   – Ruifu detail pictures

China New Product 2-Chloropropionic Acid Ethyl Ester - Rivaroxaban Intermediate CAS 446292-07-5 Purity ≥98.0% (HPLC)   – Ruifu detail pictures


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