Chinese wholesale Dichloropyrazine - (S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS 178306-52-0 Ambrisentan Intermediate Purity ≥99.0% – Ruifu

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Chinese wholesale Dichloropyrazine - (S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS 178306-52-0 Ambrisentan Intermediate Purity ≥99.0% – Ruifu Detail:

Manufacturer with High Quality
Commercial Supply Ambrisentan (CAS: 177036-94-1) Related Intermediates:
3,3-Diphenyloxirane-2-carboxylic Acid Methyl Ester CAS: 76527-25-8
Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate CAS: 178306-47-3
2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoic Acid CAS: 178306-51-9
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid CAS: 178306-52-0
L-Proline Methyl Ester Hydrochlorid CAS: 2133-40-6
4,6-Dimethyl-2-(methylsulfonyl)pyrimidine CAS: 35144-22-0

Chemical Name (S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid
Synonyms (S)-2-Hydroxyl-3-Methoxy-3,3-Diphenylpropanoic Acid
CAS Number 178306-52-0
CAT Number RF-PI162
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C16H16O4
Molecular Weight 272.30
Brand Ruifu Chemical
Item Specifications
Appearance Off-White to White Powder
Purity ≥99.0%
Moisture (K.F) ≤0.50%
Any Single Impurity ≤0.50%
Total Impurities ≤1.0%
Isomer ≤0.10%
Melting Point 115.0~125.0℃
Specific Rotation +9.5° ~ +11.5° (C=1, EtOH)
Test Standard Enterprise Standard
Usage Intermediate of Ambrisentan (CAS: 177036-94-1)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

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(S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS: 178306-52-0 Intermediate of Ambrisentan (CAS: 177036-94-1).

Ambrisentan (CAS: 177036-94-1) is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors.

Ambrisentan (CAS: 177036-94-1), (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid(Letairis), is a potent ETA selective endothelin antagonist that,is indicated, in the treatment of pulmonary arterial hypertension(PAH). PAH is a rare disease that if left untreated has ahigh mortality rate. In June of 2007, the FDA granted approvalof Ambrisentan (CAS: 177036-94-1) for once-daily treatment of PAH. Studies have shown that it improves a 6-minute walk by about30 to 60 m for patients receiving placebo.


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Chinese wholesale Dichloropyrazine - (S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS 178306-52-0 Ambrisentan Intermediate Purity ≥99.0% – Ruifu detail pictures


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Our enterprise insists all along the standard policy of "product high-quality is base of business survival; client satisfaction could be the staring point and ending of an business; persistent improvement is eternal pursuit of staff" as well as consistent purpose of "reputation first, client first" for Chinese wholesale Dichloropyrazine - (S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS 178306-52-0 Ambrisentan Intermediate Purity ≥99.0% – Ruifu , The product will supply to all over the world, such as: Brunei, Azerbaijan, Hongkong, We have 48 provincial agencies in the country. We also have stable cooperation with several international trading companies. They place order with us and export products to other countries. We expect to cooperate with you to develop a larger market.
  • In China, we have purchased many times, this time is the most successful and most satisfactory, a sincere and realiable Chinese manufacturer!
    5 Stars By Gustave from Comoros - 2018.07.27 12:26
    After the signing of the contract, we received satisfactory goods in a short term, this is a commendable manufacturer.
    5 Stars By Eileen from Poland - 2018.09.29 13:24
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