(2-Hydroxypropyl)-γ-Cyclodextrin CAS 128446-34-4 (HP-γ-CD)

(2-Hydroxypropyl)-γ-Cyclodextrin (HP-γ-CD) (CAS: 128446-34-4), Dissolve large molecules, such as cholesterol, for cell culture. Hydroxypropyl-γ-Cyclodextrin is similar to β-Cyclodextrin, but can dissolve larger molecules. Non-toxic solubilizer. γ-Cyclodextrins (8-glucose units) have a larger cavity and can accommodate a larger substrate than β-Cyclodextrin. (2-Hydroxypropyl)-γ-Cyclodextrin is a gamma cyclodextrin that is a derivative of an 8-membered sμgar ring molecule. They can solubilize hydrophobic molecules and can crosslink to form longer polymers. This overall is a very useful chemical for supramolecular chemistry.
(2-Hydroxypropyl)-γ-Cyclodextrin is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-Cyclodextrin. Enteric coating, sustained release formulations, buccal and transdermal drug delivery.
(2-Hydroxypropyl)-γ-Cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.
(2-Hydroxypropyl)-γ-Cyclodextrin products, water solubility is further improved to 80g/100mL (25℃), and after hydroxypropyl γ-Cyclodextrin is no longer a single pure product, but a mixture of multiple substitution coexistence, inclusion complex is not easy to generate crystallization precipitation when inclusion with guest molecules, in general, Hydroxypropyl-γ-Cyclodextrin has higher solubility in water and stronger resistance to crystallization. The solubility of γ-Cyclodextrin in water is 23.2g/100ml(25℃), but the solubility still limits its application in some cases. It is suggested to be used in high value-added products, such as medicine, health care products, cosmetics and other special materials or Hydroxypropyl-β-Cyclodextrin powerless inclusion of large molecular treatment.
Cyclodextrins have multiple applications. A great number of different pharmaceutical products containing cyclodextrins are currently on the market worldwide, mostly tablets, aqueous parenteral solutions, nasal sprays and eye drop solutions.
Cyclodextrins can reduce or prevent gastrointestinal and ocular irritation, reduce or eliminate unpleasant smells or tastes, prevent pre-systemic drug-drug or drug-additive interactions within a formulation or help to convert oils and liquid drugs into microcrystalline or amorphous powders.