DEPBT CAS 165534-43-0 Peptide Coupling Reagent Purity >99.0% (HPLC) Factory

Short Description:

Chemical Name: DEPBT 

CAS: 165534-43-0

Purity: >99.0% (HPLC)

White to Off-White Crystalline Powder

Peptide Coupling Reagent, High Quality 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 3-(Diethoxyphosphoryloxy)-1,2,3-Benzotriazin-4(3H)-one (DEPBT) (CAS: 165534-43-0) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase DEPBT, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name 3-(Diethoxyphosphoryloxy)-1,2,3-Benzotriazin-4(3H)-one  
Synonyms DEPBT; Diethyl 3,4-Dihydro-4-oxo-1,2,3-Benzotriazin-3-yl Phosphate; Diethyl (4-oxobenzo[d][1,2,3]triazin-3(4H)-yl) Phosphate
Stock Status In Stock, Mass Production
CAS Number 165534-43-0
Molecular Formula C11H14N3O5P 
Molecular Weight 299.22 g/mol
Melting Point 68.0~78.0℃ 
Density 1.45±0.10 g/cm3 
Sensitive Hygroscopic. Moisture Sensitive, Light Sensitive 
Solubility in Ethylacetate  Almost Transparency  
Storage Temp.  Cool & Dry Place (≤-20℃, Away from Light) 
COA & MSDS Available
Category   Coupling Reagents 
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance White to Off-White Crystalline Powder  Complies      
Melting Point 68.0~78.0℃ 72.5~73.1℃
Loss on Drying <0.50% 0.13% 
Residue on Ignition <0.20% 0.12%
Purity / Analysis Method >99.0% (HPLC)  99.8% 
Solubility in EtOAC Solution Transparent Complies
Infrared Spectrum Conforms to Structure Complies      
1 H NMR Spectrum  Conforms to Structure Complies      
Conclusion The product has been tested & complies with the specifications

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (≤-20℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

165534-43-0 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany 3

Application:

3-(Diethoxyphosphoryloxy)-1,2,3-Benzotriazin-4(3H)-one (DEPBT) (CAS: 165534-43-0) is a peptide coupling reagent used in peptide synthesis. It shows remarkable resistance to racemization. DEPBT is a coupling reagent that facilitates amide bond formation and also resists racemization. It has been shown to be more effective than phosphonium and uronium coupling reagents.
DEPBT, the highly efficient reagent for amide bond formation in synthesizing complex molecules and for peptide cyclization. Compatible for a solution and solid-phase synthesis. DEPBT is compatible with solution and SPPS.
DEPBT is an organophosphorous coupling reagent used in peptide chemistry. DEPBT is efficient in the synthesis of linear, cyclic and sterically hindered peptides, in solution and solid phase synthesis, achieving high yields with fast kinetics and remarkable retention of configuration. DEPBT can be easily synthesised, is a crystalline phosphate stable for months and shows often better performances than the commonly used phosphonium and uronium salts. Notably, in presence of DEPBT it is not necessary to protect the hydroxyl group in the amino acids (such as tyrosine, serine, and threonine) and the imidazole group of histidine. Therefore, DEPBT can be employed in the synthesis of amino alcohols and N-glycopeptides. DEPBT finds application in the synthesis of numerous bioactive peptides and complex natural products.  

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