Factory Free sample Tetracaine - Posaconazole CAS 171228-49-2 API Triazole Antifungal Agent High Quality – Ruifu

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Factory Free sample Tetracaine - Posaconazole CAS 171228-49-2 API Triazole Antifungal Agent High Quality – Ruifu Detail:

Manufacturer Supply with High Purity and Stable Quality
Chemical Name: Posaconazole
CAS: 171228-49-2
Posaconazole is a Triazole Antifungal Agent
API High Quality, Commercial Production

Chemical Name	Posaconazole
Synonyms	4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
CAS Number	171228-49-2
CAT Number	RF-API77
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C37H42F2N8O4
Molecular Weight	700.78
Density	1.36 g/cm3
Solubility	Soluble in DMSO, Insoluble in Water
Shipping Condition	Shipped Under Ambient Temperature
Brand	Ruifu Chemical

Item	Specifications
Appearance	White to Off-White Crystalline Powder
Identification A	IR: The infrared absorption spectrum of the product should be consistent with that of the reference substance
Identification B	HPLC Retention time similar to reference substance
Melting Point	167.0~171.0℃
Specific Rotation [a]20	-24.0° ~ -28.0° (C=1, CHCL3)
Water (K.F)	≤1.0%
Residue on Ignition	≤0.10%
Related Substances
HT 909-24	≤0.20%
Any Individual Impurity	≤0.10%
Total Impurities	≤1.0%
Residual Solvents
Methanol	≤3000ppm
Methyl tert-Butyl Ether	≤5000ppm
Isopropanol	≤5000ppm
Dimethyl Sulfoxide	≤5000ppm
Dichloromethane	≤600ppm
Assay	98.0%~102.0% (Calculated on the dried basis)
Heavy Metals	≤10ppm
Isomer	Enantiomer ≤0.10%
	Any Individual Impurity ≤0.10%
	Total Impurities ≤1.0%
Test Standard	Enterprise Standard; USP; BP; EP Standard
Usage	API, Triazole Antifungal Agent

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Posaconazole (CAS 171228-49-2), is a broad-spectrum, second generation, triazole compound with antifungal activity, launched in the UK, is the newest member of the azole class of antifungal agents to reach the market. It is indicated for the treatment and prophylaxis of a range of invasive fungal infections, including aspergillosis,fusariosis, chromoblastomycosis, mycetoma, and coccidiomycosis in patients who are refractory to, or intolerant of, standard therapy with amphotericin B and/or itraconazole. In the US, it is approved for the prophylaxis of invasive Aspergillus and Candida infections in patients 13 years of age who are at high risk of developing these infections due to being severely immunocompromised. Additionally, it is approved for the treatment of oropharyngeal candidiasis. Posaconazole has an expanded spectrum of activity over other members of the azole antifungals. In addition to potent activity against refractory cases of aspergillosis and fluconazole-resistant Candida, it demonstrates activity against Zygomycetes. Posaconazole is a triazole antifungal drug marketed in the United States by Schering-Plough under the trade name Noxafil.

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