Factory Outlets DL-Ethyl 4-Chloro-3-Hydroxybutyrate - (S)-3-Hydroxypyrrolidine Hydrochloride CAS 122536-94-1 Darifenacin Hydrobromide Intermediate – Ruifu
Factory Outlets DL-Ethyl 4-Chloro-3-Hydroxybutyrate - (S)-3-Hydroxypyrrolidine Hydrochloride CAS 122536-94-1 Darifenacin Hydrobromide Intermediate – Ruifu Detail:
Manufacturer with High Purity and Competitive Price
Commercial Supply Darifenacin Hydrobromide Related Intermediates:
(S)-3-Hydroxypyrrolidine Hydrochloride CAS: 122536-94-1
(S)-α,α-Diphenyl-3-Pyrrolidineacetamide L-Tartrate CAS: 134002-26-9
(S)-2,2-Diphenyl-2-(Pyrrolidin-3-yl)acetonitrile Hydrobromide CAS: 194602-27-2
(S)-2,2-Diphenyl-2-(1-Tosylpyrrolidin-3-yl)acetonitrile CAS: 133099-09-9
2,3-Dihydrobenzofuran CAS: 496-16-2
2,3-Dihydrobenzofuranyl-5-Acetic Acid CAS: 69999-16-2
5-(2-Bromoethyl)-2,3-Dihydrobenzofuran CAS: 127264-14-6
Darifenacin Hydrobromide CAS: 133099-07-7
| Chemical Name | (S)-3-Hydroxypyrrolidine Hydrochloride |
| Synonyms | (S)-3-Hydroxypyrrolidine HCl; (S)-3-Pyrrolidinol Hydrochloride; (S)-Pyrrolidin-3-ol (Hydrochloride); (S)-Pyrrolidin-3-ol, HCl |
| CAS Number | 122536-94-1 |
| CAT Number | RF-CC103 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C4H10ClNO |
| Molecular Weight | 123.581 |
| Melting Point | 104°C to 107°C |
| Boiling Point | 108°C to 110°C (8mmHg) |
| Solubility | DMSO (Sparingly), Methanol (Slightly) |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Off-White to Brown Crystalline Powder |
| Purity / Analysis Method | ≥98.0% (GC) |
| Specific Rotation | +6.5° ~ +8.5° (C=3 CH3OH) |
| Any Individual Impurity | ≤0.50% |
| Total Impurities | ≤1.0% |
| Loss on Drying | ≤0.50% |
| Residue on Ignition | ≤0.50% |
| Test Standard | Enterprise Standard |
| Usage | Darifenacin Hydrobromide Intermediate |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
How to purchase?
Please contact: sales@ruifuchem.com
QA (Quality Assurance)?
Reliable quality assurance, strict management. Professional equipment for analysis include NMR, LC-MS, GC-MS, HPLC, UPCC/HPLC, GC-HS, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Free Samples?
Free samples for quality evaluation available.
Factory Audit?
Factory audit welcome. Please make an appointment in advance.
MOQ?
No MOQ. Small order is acceptable.
Delivery time?
If within stock, three days delivery guaranteed
Transportation?
By Express(FedEx, DHL), by Air, by sea.
Custom Synthesis?
Can provide custom synthesis services.
Payment terms?
T/T(telex transfer), PayPal, Western Union, etc.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-3-Hydroxypyrrolidine Hydrochloride (CAS: 122536-94-1) with high quality, widely used in organic synthesis, synthesis of pharmaceutical intermediates and Active Pharmaceutical Ingredient (API) synthesis. (S)-3-Hydroxypyrrolidine Hydrochloride (CAS: 122536-94-1) is the main intermediate of Darifenacin Hydrobromide (CAS: 133099-07-7)
(S)-3-Hydroxypyrrolidine hydrochloride was synthesized from(S)-4-amino-2-hydroxybutyric acid through silanization and cyclization to yield(S)-3-trimethylsilyoxy-2-pyrrolidinone,which was subsequently subjected to reduction and formation of hydrochloride salt.The influence of different reduction agents,molar ratio,and solvent on the yield was investigated.The optimal conditions were as follows:NaBH4-CH3COOH was used as the reducing agent,1,4-dioxane was used as the solvent,the molar ratio of 2-amino-3-hydroxybutyric acid to NaBH4 and acetic acid was 1:5:5,and the reaction time was 5 h at 110～120 ℃.The overall yield of target compound was increased to 65%.The process has such advantages as inexpensive reagents,high yield and simple operation.
Darifenacin Hydrobromide (CAS: 133099-07-7), an orally active, once a day selective M3 receptor antagonist, was launched for the treatment of overactive bladder in patients with symptoms of urge urinary incontinence, urgency and frequency. The drug selectively inhibits M3 receptor in the detrusor muscle while sparing the M1 and M2 receptors that are believed to be involved in central nervous system and cardiovascular function respectively. The compound was originally developed by Pfizer and licensed to Novartis and Bayer.
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It really is a good way to further improve our goods and service. Our mission would be to acquire inventive items to buyers with a very good encounter for Factory Outlets DL-Ethyl 4-Chloro-3-Hydroxybutyrate - (S)-3-Hydroxypyrrolidine Hydrochloride CAS 122536-94-1 Darifenacin Hydrobromide Intermediate – Ruifu , The product will supply to all over the world, such as: Australia, Belize, Turkey, We believe in establishing healthy customer relationships and positive interaction for business. Close cooperation with our customers has helped us to create strong supply chains and reap benefits. Our products have gained us widespread acceptance and the satisfaction of our worldwide valued clients.
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By Maxine from Algeria - 2017.02.18 15:54
Cooperate with you every time is very successful, very happy. Hope that we can have more cooperation!
By Polly from USA - 2018.10.09 19:07