factory Outlets for Eflornithine Hydrochloride Monohydrate - Imatinib Mesylate (alpha form) CAS 220127-57-1 Ph+CML API High Quality – Ruifu

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factory Outlets for Eflornithine Hydrochloride Monohydrate - Imatinib Mesylate (alpha form) CAS 220127-57-1 Ph+CML API High Quality – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Commercial Supply Imatinib Mesylate (CAS: 220127-57-1) and Related Intermediates:
Imatinib Mesylate (alpha form) CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8

Chemical Name	Imatinib Mesylate (alpha form)
Synonyms	STI571 Mesylate; CGP-57148B; Imatinib Methanesulfonate
CAS Number	220127-57-1
CAT Number	RF-API19
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C30H35N7O4S
Molecular Weight	589.71
Brand	Ruifu Chemical

Item	Specifications
Appearance	White to Off-White Crystalline Powder
Solubility	Easy to dissolve in the water
HPLC Identification	Sample spectrum main peak retention time conforms with that
IR Identification	Infrared absorption spectrum of sample conforms with reference sample
Melting Point	214.0~222.0℃
Loss on Drying	≤0.50%
Residue on Ignition	≤0.10%
Heavy Metals	≤20ppm
Related Substances	(1) Impurity G: NMT 0.3%
	(2) Impurity B: NMT 0.3%
	(3) Impurity C: NMT 0.3%
	(4) Impurity D: NMT 0.3%
	(5) Impurity A: NMT 0.3%
	(6) Impurity H: NMT 0.3%
	(7) Impurity F: NMT 0.3%
	(8) Impurity E: NMT 0.3%
	(9) The biggest single impurity: NMT0.1%
Residual Solvents	(1) Ethyl Acetate: NMT 5000ppm
	(2) Methanol: NMT3000ppm
	(3) Dichloromethane: NMT 600ppm
	(4) Ethanol: NMT 5000ppm
	(5) Toluene: NMT 890ppm
	(6) Dimethyl Sulfoxide: NMT5000ppm
HPLC Assay	98.0%~102.0% (C30H35N7SO4 Calculated on the Anhydrous Basis)
Test Standard	Enterprise Standard
Usage	Active Pharmaceutical Ingredient (API); Ph+CML

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Imatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). A translocation event between chromosomes 9 and 22 generates the Philadelphia chromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib mesylate binds up this crucial kinase, halting CML related growth. Imatinib mesylate has further been displayed to inhibit PDGFR and tyrosine kinases associated with c-Kit. Formulations containing Imatinib mesylate have been used in the treatment of various cancers.

Imatinib mesylate is A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It’s a potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 9.823 and 17.689 μM, respectively).

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