Factory Price (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1 3-oxazolidin-2-one - 4-(4-Aminophenyl)morpholin-3-One CAS 438056-69-0 Rivaroxaban Intermediate – Ruifu

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Factory Price (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1 3-oxazolidin-2-one - 4-(4-Aminophenyl)morpholin-3-One CAS 438056-69-0 Rivaroxaban Intermediate – Ruifu Detail:

Manufacturer with High Purity and Competitive Price
Commercial Supply Rivaroxaban (CAS: 366789-02-8) Related Intermediates:
(S)-(+)-Glycidyl Phthalimide CAS: 161596-47-0
4-(4-Aminophenyl)morpholin-3-one CAS: 438056-69-0
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione 446292-07-5
5-Chlorothiophene-2-carboxylic acid CAS: 24065-33-6
Rivaroxaban CAS: 366789-02-8

Chemical Name	4-(4-Aminophenyl)morpholin-3-one
CAS Number	438056-69-0
CAT Number	RF-PI129
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C10H12N2O2
Molecular Weight	192.21
Brand	Ruifu Chemical

Item	Specifications
Appearance	White to Light Yellow or Light Brown Crystalline Powder
Purity / Analysis Method	≥99.0% (HPLC)
Melting Point	165.0~175.0°C
Identification	HNMR
Moisture (K.F)	≤1.0%
Loss on Drying	≤0.50%
Residue on lgnition	≤0.10%
Max Single Impurity	≤0.50%
Total Impurities	≤1.5%
Test Standard	Enterprise Standard
Usage	Rivaroxaban (CAS: 366789-02-8) Intermediate

4-(4-Aminophenyl)morpholin-3-one CAS: 438056-69-0 Synthesis Route

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

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Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 4-(4-Aminophenyl)morpholin-3-one (CAS: 438056-69-0) with high quality, it is an intermediate typically in the synthesis of Rivaroxaban (CAS: 366789-02-8).

Rivaroxaban (Xarelto; CAS: 366789-02-8) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. Rivaroxaban also inhibits prothrombinase activity with IC50 of 2.1 nM. Rivaroxaban also shows a similar affinity to purified human and rabbit FXa (IC50 0.7 nM and 0.8 nM, respectively), but a lesser potency against purified rat FXa (IC50 3.4 nM). Endogenous human and rabbit FXa in plasma is inhibited to a similar extent by Rivaroxaban (IC50 21 nM and 21 nM, respectively), while 14-fold higher concentrations are required in rat plasma (IC50 290 nM). Rivaroxaban exhibits high permeability and polarized transport across Caco-2 cells as a substrate of the P-gp, but exhibits no inhibitory effect on P-gp-mediated drug transport up to concentrations of 100 μM in vitro.

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