Factory Price Ethyl 4-Chloro-3-Hydroxybutanoate - N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity – Ruifu

Short Description:

Product Detail

Product Tags

Feedback (2)

With advanced technologies and facilities, strict high quality regulate, reasonable price tag, excellent support and close co-operation with shoppers, we have been devoted to furnishing the best benefit for our buyers for CAS 538-75-0, Atorvastatin ATS-8, Molecular Formula C15H21NO4, We are sincerely looking forward to cooperate with customers all over the world. We believe we can satisfy with you. We also warmly welcome customers to visit our factory and purchase our products.

Factory Price Ethyl 4-Chloro-3-Hydroxybutanoate - N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Commercial Supply Imatinib Mesylate (CAS: 220127-57-1) and Related Intermediates:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8

Chemical Name	N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea
Synonyms	Imatinib Mesylate Intermediate; 2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine
CAS Number	152460-10-1
CAT Number	RF-PI230
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C16H15N5
Molecular Weight	277.32
Melting Point	133.0-135.0℃
Brand	Ruifu Chemical

Item	Specifications
Appearance	Light Orange to Yellow Powder to Crystal
Purity / Analysis Method	≥98.0%
Loss on Drying	≤0.50%
Residue on ignition	≤0.50%
Total Impurities	≤2.0%
Maximum Single Impurity	≤1.0%
Heavy Metals	≤20ppm
Test Standard	Enterprise Standard
Usage	Intermediate of Imatinib Mesylate (CAS: 220127-57-1)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) with high quality.
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) is an intermediate typically in the synthesis of Imatinib Mesylate (CAS: 220127-57-1) API.
Imatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). A translocation event between chromosomes 9 and 22 generates the Philadelphia chromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib mesylate binds up this crucial kinase, halting CML related growth. Imatinib mesylate has further been displayed to inhibit PDGFR and tyrosine kinases associated with c-Kit. Formulations containing Imatinib mesylate have been used in the treatment of various cancers.
Imatinib mesylate is A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It’s a potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 9.823 and 17.689 μM, respectively).

Product detail pictures:

Related Product Guide:

To be the stage of realizing dreams of our employees! To build a happier, more united and more professional team! To reach a mutual benefit of our customers, suppliers, the society and ourselves for Factory Price Ethyl 4-Chloro-3-Hydroxybutanoate - N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity – Ruifu , The product will supply to all over the world, such as: Ecuador, Anguilla, Florence, Our continual availability of high grade products in combination with our excellent pre-sale and after-sales service ensures strong competitiveness in an increasingly globalized market. welcome new and old customers from all walks of life to contact us for future business relationships and mutual success!