Factory Supply Acetylacetone - 2′,3′-Di-O-acetyl-5′-deoxy-5-fluorocytidine CAS 161599-46-8 Purity ≥99.0% Capecitabine Intermediate – Ruifu

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Factory Supply Acetylacetone - 2′,3′-Di-O-acetyl-5′-deoxy-5-fluorocytidine CAS 161599-46-8 Purity ≥99.0% Capecitabine Intermediate – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Commercial Supply Capecitabine (CAS: 154361-50-9) Related Intermediates:
5-Fluorocytosine CAS: 2022-85-7
2′,3′-Di-O-acetyl-5′-deoxy-5-fluorocytidine CAS: 161599-46-8
1,2,3-Tri-O-acetyl-5-deoxy-β-D-ribofuranose CAS: 62211-93-2
Capecitabine CAS: 154361-50-9

Name	2′,3′-Di-O-acetyl-5′-deoxy-5-fluorocytidine
CAS Number	161599-46-8
CAT Number	RF-PI176
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C13H16FN3O6
Molecular Weight	329.28
Condition to Avoid	Heat Sensitive
Brand	Ruifu Chemical

Item	Specifications
Appearance	Whitish or Yellowish Crystalline Powder
Single Impurity	≤0.50%
Total Impurities	≤1.0%
Melting Point	178.0~193.0℃
Loss on Drying	≤0.50%
Residue on Ignition	≤0.10%
Moisture (K.F)	≤1.0%
Assay	≥99.0%
Purity / Analysis Method	≥99.0% (HPLC)
Test Standard	Enterprise Standard
Usage	Intermediate of Capecitabine (CAS: 154361-50-9)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Capecitabine is a new oral fluoropyrimidine carbamate for patients with advanced neoplastic disease, approved as Xeloda for the treatment of refractory metastatic breast cancer after failure on Paclitaxel and an anthracycline-based chemotherapy regimen ; it is a prodrug of doxifluridine (5-fluorouracil ; 5-FU) activated by a cascade of 3 enzymes concentrated in human liver and cancer tissue, resulting in the selective release of 5-FU at the tumor site and offering a prolonged tumour exposure to 5-FU. Oral Capecitabine passes intact through the intestinal mucosa, is converted first by carboxylesterase to 5′-deoxy-5- fluorocytidine in the liver, then by cytidine deaminase to 5′-deoxy-5-fluorouridine in the liver and tumour tissues and finally by thymidine phosphorylase to 5-FU in tumors. Therefore, Xeloda is much safer and more effective than 5-FU (for example, in the HCT116 human colon cancer and the MX-1 breast cancer xenograft .models).

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