Good quality Boc-L-leucine Monohydrate - (S)-3-Hydroxypyrrolidine Hydrochloride CAS 122536-94-1 Darifenacin Hydrobromide Intermediate – Ruifu

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Dedicated to strict quality management and thoughtful client services, our experienced staff customers are generally available to discuss your demands and guarantee full client pleasure for 654655-68-2, (S)-3-Pyrrolidinol hydrochloride, Weight 178.14, "Quality first, Price lowest, Service best" is the spirit of our company. We sincerely welcome you to visit our company and negotiate mutual business!

Good quality Boc-L-leucine Monohydrate - (S)-3-Hydroxypyrrolidine Hydrochloride CAS 122536-94-1 Darifenacin Hydrobromide Intermediate – Ruifu Detail:

Manufacturer with High Purity and Competitive Price
Commercial Supply Darifenacin Hydrobromide Related Intermediates:
(S)-3-Hydroxypyrrolidine Hydrochloride CAS: 122536-94-1
(S)-α,α-Diphenyl-3-Pyrrolidineacetamide L-Tartrate CAS: 134002-26-9
(S)-2,2-Diphenyl-2-(Pyrrolidin-3-yl)acetonitrile Hydrobromide CAS: 194602-27-2
(S)-2,2-Diphenyl-2-(1-Tosylpyrrolidin-3-yl)acetonitrile CAS: 133099-09-9
2,3-Dihydrobenzofuran CAS: 496-16-2
2,3-Dihydrobenzofuranyl-5-Acetic Acid CAS: 69999-16-2
5-(2-Bromoethyl)-2,3-Dihydrobenzofuran CAS: 127264-14-6
Darifenacin Hydrobromide CAS: 133099-07-7

Chemical Name	(S)-3-Hydroxypyrrolidine Hydrochloride
Synonyms	(S)-3-Hydroxypyrrolidine HCl; (S)-3-Pyrrolidinol Hydrochloride; (S)-Pyrrolidin-3-ol (Hydrochloride); (S)-Pyrrolidin-3-ol, HCl
CAS Number	122536-94-1
CAT Number	RF-CC103
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C4H10ClNO
Molecular Weight	123.581
Melting Point	104°C to 107°C
Boiling Point	108°C to 110°C (8mmHg)
Solubility	DMSO (Sparingly), Methanol (Slightly)
Brand	Ruifu Chemical

Item	Specifications
Appearance	Off-White to Brown Crystalline Powder
Purity / Analysis Method	≥98.0% (GC)
Specific Rotation	+6.5° ~ +8.5° (C=3 CH3OH)
Any Individual Impurity	≤0.50%
Total Impurities	≤1.0%
Loss on Drying	≤0.50%
Residue on Ignition	≤0.50%
Test Standard	Enterprise Standard
Usage	Darifenacin Hydrobromide Intermediate

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

How to purchase?
Please contact: sales@ruifuchem.com

QA (Quality Assurance)?
Reliable quality assurance, strict management. Professional equipment for analysis include NMR, LC-MS, GC-MS, HPLC, UPCC/HPLC, GC-HS, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Free Samples?
Free samples for quality evaluation available.

Factory Audit?
Factory audit welcome. Please make an appointment in advance.

MOQ?
No MOQ. Small order is acceptable.

Delivery time?
If within stock, three days delivery guaranteed

Transportation?
By Express(FedEx, DHL), by Air, by sea.

Custom Synthesis?
Can provide custom synthesis services.

Payment terms?
T/T(telex transfer), PayPal, Western Union, etc.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-3-Hydroxypyrrolidine Hydrochloride (CAS: 122536-94-1) with high quality, widely used in organic synthesis, synthesis of pharmaceutical intermediates and Active Pharmaceutical Ingredient (API) synthesis. (S)-3-Hydroxypyrrolidine Hydrochloride (CAS: 122536-94-1) is the main intermediate of Darifenacin Hydrobromide (CAS: 133099-07-7)

(S)-3-Hydroxypyrrolidine hydrochloride was synthesized from(S)-4-amino-2-hydroxybutyric acid through silanization and cyclization to yield(S)-3-trimethylsilyoxy-2-pyrrolidinone,which was subsequently subjected to reduction and formation of hydrochloride salt.The influence of different reduction agents,molar ratio,and solvent on the yield was investigated.The optimal conditions were as follows:NaBH4-CH3COOH was used as the reducing agent,1,4-dioxane was used as the solvent,the molar ratio of 2-amino-3-hydroxybutyric acid to NaBH4 and acetic acid was 1:5:5,and the reaction time was 5 h at 110～120 ℃.The overall yield of target compound was increased to 65%.The process has such advantages as inexpensive reagents,high yield and simple operation.

Darifenacin Hydrobromide (CAS: 133099-07-7), an orally active, once a day selective M3 receptor antagonist, was launched for the treatment of overactive bladder in patients with symptoms of urge urinary incontinence, urgency and frequency. The drug selectively inhibits M3 receptor in the detrusor muscle while sparing the M1 and M2 receptors that are believed to be involved in central nervous system and cardiovascular function respectively. The compound was originally developed by Pfizer and licensed to Novartis and Bayer.

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