Good User Reputation for Irinotecan - Imatinib Mesylate (alpha form) CAS 220127-57-1 Ph+CML API High Quality – Ruifu
Good User Reputation for Irinotecan - Imatinib Mesylate (alpha form) CAS 220127-57-1 Ph+CML API High Quality – Ruifu Detail:
Manufacturer with High Purity and Stable Quality
Commercial Supply Imatinib Mesylate (CAS: 220127-57-1) and Related Intermediates:
Imatinib Mesylate (alpha form) CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
Chemical Name | Imatinib Mesylate (alpha form) |
Synonyms | STI571 Mesylate; CGP-57148B; Imatinib Methanesulfonate |
CAS Number | 220127-57-1 |
CAT Number | RF-API19 |
Stock Status | In Stock, Production Scale Up to Tons |
Molecular Formula | C30H35N7O4S |
Molecular Weight | 589.71 |
Brand | Ruifu Chemical |
Item | Specifications |
Appearance | White to Off-White Crystalline Powder |
Solubility | Easy to dissolve in the water |
HPLC Identification | Sample spectrum main peak retention time conforms with that |
IR Identification | Infrared absorption spectrum of sample conforms with reference sample |
Melting Point | 214.0~222.0℃ |
Loss on Drying | ≤0.50% |
Residue on Ignition | ≤0.10% |
Heavy Metals | ≤20ppm |
Related Substances | (1) Impurity G: NMT 0.3% |
(2) Impurity B: NMT 0.3% | |
(3) Impurity C: NMT 0.3% | |
(4) Impurity D: NMT 0.3% | |
(5) Impurity A: NMT 0.3% | |
(6) Impurity H: NMT 0.3% | |
(7) Impurity F: NMT 0.3% | |
(8) Impurity E: NMT 0.3% | |
(9) The biggest single impurity: NMT0.1% | |
Residual Solvents | (1) Ethyl Acetate: NMT 5000ppm |
(2) Methanol: NMT3000ppm | |
(3) Dichloromethane: NMT 600ppm | |
(4) Ethanol: NMT 5000ppm | |
(5) Toluene: NMT 890ppm | |
(6) Dimethyl Sulfoxide: NMT5000ppm | |
HPLC Assay | 98.0%~102.0% (C30H35N7SO4 Calculated on the Anhydrous Basis) |
Test Standard | Enterprise Standard |
Usage | Active Pharmaceutical Ingredient (API); Ph+CML |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Imatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). A translocation event between chromosomes 9 and 22 generates the Philadelphia chromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib mesylate binds up this crucial kinase, halting CML related growth. Imatinib mesylate has further been displayed to inhibit PDGFR and tyrosine kinases associated with c-Kit. Formulations containing Imatinib mesylate have been used in the treatment of various cancers.
Imatinib mesylate is A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It’s a potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 9.823 and 17.689 μM, respectively).
Product detail pictures:
Related Product Guide:
Fast and superior quotations, informed advisers to help you choose the correct merchandise that suits all your requirements, a short generation time, responsible quality control and different services for paying and shipping affairs for Good User Reputation for Irinotecan - Imatinib Mesylate (alpha form) CAS 220127-57-1 Ph+CML API High Quality – Ruifu , The product will supply to all over the world, such as: Iran, Burundi, Portland, By integrating manufacturing with foreign trade sectors, we can offer total customer solutions by guaranteeing the delivery of right items to the right place at the right time, which is supported by our abundant experiences, powerful production capability, consistent quality, diversified product portfolios and the control of the industry trend as well as our mature before and after sales services. We'd like to share our ideas with you and welcome your comments and questions.
By Novia from Poland - 2018.04.25 16:46
The factory technical staff not only have high level of technology, their English level is also very good, this is a great help to technology communication.
By Raymond from Serbia - 2017.12.19 11:10