High Quality for Acetaminophen - Guanfacine Hydrochloride Guanfacine HCl CAS 29110-48-3 API USP Standard High Purity – Ruifu

Manufacturer with High Purity and Stable Quality
Chemical Name: Guanfacine Hydrochloride
Synonyms: Guanfacine HCl
CAS: 29110-48-3 
Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist. Antihypertensive
API High Quality, Commercial Production 

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Guanfacine Hydrochloride (CAS: 29110-48-3) with high quality.
Guanfacine hydrochloride centrally acting a-adrenoceptor agonist. Antihypertensive. Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors. IC50 Value: 31 nM(Kd) Target: Adrenergic Receptor Guanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone. The therapeutic applications for guanfacine are similar to those of the other centrally acting α2-adrenergic agonists and methyldopa. It has been effective as monotherapy in the treatment of patients with mild to moderate hypertension. One advantage for guanfacine is its once-a-day dosing schedule. The use of diuretics to prevent accumulation of fluid may allow a reduction in the dosage for guanfacine.