Ki16425 CAS 355025-24-0 Purity >98.0% (HPLC) LPA Receptor Antagonist

Short Description:

Chemical Name: Ki16425

CAS: 355025-24-0

Purity: >98.0% (HPLC)

Appearance: White or Off-White Solid

Potent and Reversible LPA1 and LPA3 Receptor Antagonist

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

355025-24-0 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Ki16425 (CAS: 355025-24-0) with high quality, potent and reversible antagonist of the lysophosphatidic acid receptors LPA1 and LPA3.
Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Ki16425 or other products, please contact us by e-mail: alvin@ruifuchem.com

355025-24-0 - Chemical Properties:

Chemical Name	Ki16425
Synonyms	Ki-16425; Ki 16425; CS-88; Debio 0719; 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl] methyl]thio]-propanoic acid; 3-[({4-[4-({[1-(2-Chlorophenyl)ethoxy]carbonyl} amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid
CAS Number	355025-24-0
Molecular Formula	C23H23ClN2O5S
Molecular Weight	474.96 g/mol
Melting Point	59.5-60.5℃
Density	1.353
Solubility	DMSO: 20 mg/mL, Clear
Storage Temperature	Store Long-Term at -20℃
COA & MSDS	Available
Origin of Product	Shanghai, China
Application(s)	Antagonist of the Lysophosphatidic Acid Receptors LPA1 and LPA3
Caution	Not For Human or Veterinary Use. For Research Use Only.
Brand	Ruifu Chemical

355025-24-0 - Specifications:

Items	Specifications	Results
Appearance	White or Off-White Solid	Conforms
Purity / Analysis Method	>98.0% (HPLC)	99.11%
1H NMR Spectrum	Consistent with Structure	Conforms
Mass Spectrum	Consistent with Structure	Conforms
Conclusion	The product has been tested and complies with the given specifications

355025-24-0 - Package/Storage/Shipping:

Package: Bottle, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (-20℃), well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

355025-24-0 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

355025-24-0 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

355025-24-0 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany 3
HS Code 2934 9990.91

355025-24-0 - Application:

Ki16425 (CAS: 355025-24-0) has been used as a chemical inhibitor to study the regulation of LPA (lysophosphatidic acid) on LPAR (LPA receptor) subtypes. Ki16425 is a competitive, potent and reversible LPA1 and LPA3 receptor antagonist.
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 μM for the human LPA1, LPA2, and LPA3 receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells. Ki1642, at 10 μM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration.