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Manufacturer of Fingolimod Hydrochloride - Palonosetron Hydrochloride CAS 135729-62-3 Purity ≥99.0% API USP EP Factory High Quality – Ruifu Featured Image
  • Manufacturer of Fingolimod Hydrochloride - Palonosetron Hydrochloride CAS 135729-62-3 Purity ≥99.0% API USP EP Factory High Quality – Ruifu

Manufacturer of Fingolimod Hydrochloride - Palonosetron Hydrochloride CAS 135729-62-3 Purity ≥99.0% API USP EP Factory High Quality – Ruifu

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Manufacturer of Fingolimod Hydrochloride - Palonosetron Hydrochloride CAS 135729-62-3 Purity ≥99.0% API USP EP Factory High Quality – Ruifu Detail:

Commercial Supply Palonosetron Hydrochloride and Related Intermediates:  
(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Naphthoic Acid CAS: 86-55-5
Palonosetron Hydrochloride CAS: 135729-62-3 API

Chemical Name Palonosetron Hydrochloride
Synonyms Palonosetron HCl
CAS Number 135729-62-3 
CAT Number RF-API03
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C19H24N2O·HCl
Molecular Weight 332.87
Condition to Avoid Heat Sensitive
Melting Point 307℃ (dec.)
Solubility in Water Completely Soluble
Brand Ruifu Chemical
Item Specifications
Appearance White or Off-White Crystalline Powder 
Purity ≥99.0%
Specific Rotation -98°～-104°
Identification Add BiI7K4，Generate Orange Yellow Precipitate
Identification TLC Consistent with the Reference Substance
Identification IR Consistent with Standard IR
Identification Identification as Chloride
Solubility Freely Soluble in water, sparingly soluble in Methanol, very slightly soluble in ethanol, insoluble in acetone
Clarity and Color of Solution Max. Yellow No. 2 Standard Color Solution
pH Vaule 4.5~6.5 (10mg/ml)
Related Sustances
Related Compound A (N-O) ≤0.10%
Related Compound B (Ene-N-O) ≤0.10%
Related Compound C (S,R) ≤0.10%
Related Compound D (R,S) ≤0.50%
Palonosetron Enantiomer ≤0.10%
Related Compound E (3-Ene) ≤0.50%
Single Unspecified Impurity ≤0.10%
Residual Solvents
Ethanol ≤3000ppm
Tetrahydrofuran ≤5000ppm
DMF ≤880ppm
Normal Hexane ≤290ppm
Methyl Alcohol ≤3000ppm
Isopropanol ≤5000ppm 
Methylbenzene ≤890ppm
Water ≤0.30%
Residue On Ignition ≤0.10%
Loss on Drying ≤1.0%
Heavy Metals ≤10ppm
Test Standard United States Pharmacopoeia (USP); European Pharmacopoeia (EP)
Usage Palonosetron Hydrochloride (CAS: 135729-62-3) API 

Package: Bottle, Cardboard Drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

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Palonosetron Hydrochloride (CAS: 135729-62-3) is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention.

With 1,2,3,4-Tetrahydro-1-Naphthoic Acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron. Clinical studies showed that palonosetron can be used safely with corticosteroids, analgesics, antiemetics, antispasmodics and anticholinergic drugsas the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron. 

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Persisting in "High high quality, Prompt Delivery, Aggressive Price", we've established long-term cooperation with clients from the two overseas and domestically and get new and old clients' superior comments for Manufacturer of Fingolimod Hydrochloride - Palonosetron Hydrochloride CAS 135729-62-3 Purity ≥99.0% API USP EP Factory High Quality – Ruifu , The product will supply to all over the world, such as: Bahamas, Swiss, Honduras, Our company always concentrate on the development of the international market. We have a lot of customers in Russia , European countries, the USA, the Middle East countries and Africa countries. We always follow that quality is foundation while service is guarantee to meet all customers.
    • We are really happy to find such a manufacturer that ensuring product quality at the same time the price is very cheap.
    5 Stars By Lee from Accra - 2018.02.08 16:45
    The factory technical staff not only have high level of technology, their English level is also very good, this is a great help to technology communication.
    5 Stars By Mabel from Jersey - 2017.09.26 12:12
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