Manufacturing Companies for ATS-9 - N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity – Ruifu

Short Description:

Product Detail

Product Tags

Feedback (2)

Our goods are commonly recognized and reliable by consumers and may satisfy continually developing economic and social needs for Weight 386.36, Molecular Formula C9H9NO2, Remdesivir CAS 1809249-37-3, We sincerely welcome overseas consumers to consult for your long-term cooperation as well as the mutual advancement.We strongly think that we will do superior and far better.

Manufacturing Companies for ATS-9 - N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Commercial Supply Imatinib Mesylate (CAS: 220127-57-1) and Related Intermediates:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8

Chemical Name	N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea
Synonyms	Imatinib Mesylate Intermediate; 2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine
CAS Number	152460-10-1
CAT Number	RF-PI230
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C16H15N5
Molecular Weight	277.32
Melting Point	133.0-135.0℃
Brand	Ruifu Chemical

Item	Specifications
Appearance	Light Orange to Yellow Powder to Crystal
Purity / Analysis Method	≥98.0%
Loss on Drying	≤0.50%
Residue on ignition	≤0.50%
Total Impurities	≤2.0%
Maximum Single Impurity	≤1.0%
Heavy Metals	≤20ppm
Test Standard	Enterprise Standard
Usage	Intermediate of Imatinib Mesylate (CAS: 220127-57-1)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) with high quality.
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) is an intermediate typically in the synthesis of Imatinib Mesylate (CAS: 220127-57-1) API.
Imatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). A translocation event between chromosomes 9 and 22 generates the Philadelphia chromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib mesylate binds up this crucial kinase, halting CML related growth. Imatinib mesylate has further been displayed to inhibit PDGFR and tyrosine kinases associated with c-Kit. Formulations containing Imatinib mesylate have been used in the treatment of various cancers.
Imatinib mesylate is A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It’s a potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 9.823 and 17.689 μM, respectively).

Product detail pictures:

Related Product Guide:

Our business puts emphasis over the administration, the introduction of talented staff, plus the construction of team building, attempting hard to boost the standard and liability consciousness of personnel customers. Our corporation successfully attained IS9001 Certification and European CE Certification of Manufacturing Companies for ATS-9 - N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity – Ruifu , The product will supply to all over the world, such as: Southampton, Montpellier, Azerbaijan, Our company always concentrate on the development of the international market. We've got a lot of customers in Russia , European countries, the USA, the Middle East countries and Africa countries. We always follow that quality is foundation while service is guarantee to meet all customers.