Methyl 2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoate CAS 178306-47-3 Purity ≥99.0% Factory

Methyl 2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoate (CAS: 178306-47-3), Intermediate of API (CAS: 177036-94-1). (CAS: 177036-94-1) is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting.