New Delivery for Pregabalin - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu

Short Description:


Product Detail

Related Products

Product Tags

Related Video

Feedback (2)

We have now probably the most innovative production equipment, experienced and qualified engineers and workers, regarded high quality control systems and also a friendly expert income team pre/after-sales support for CAS 43229-65-8, CAS 147098-20-2, H-Pro-NH2, We wish to just take this opportunity to ascertain long-term enterprise relationships with clients from all over the earth.
New Delivery for Pregabalin - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Chemical Name: Gemcitabine Hydrochloride 
CAS: 122111-03-9 
An Anticancer Agent
API USP Standard, High Quality, Commercial Production

Chemical Name Gemcitabine Hydrochloride
Synonyms Gemcitabine HCl; 2′-Deoxy-2′,2′-difluorocytidine; dFdC
CAS Number 122111-03-9
CAT Number RF-API41
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C9H12ClF2N3O4
Molecular Weight 299.66
Brand Ruifu Chemical
Item Specifications
Appearance White Crystal Powder, Odorless
Solubility Soluble in Water, slightly soluble in methanol, practically insoluble in acetone
Identifiaction IR IR spectrum should be concordant to that of the reference standard
Identifiaction Chloride Positive. It meets the requirements of the tests for chloride
Appearance of Solution Solution S in clear and not more intensely colored than reference solution BY7
pH 2.0~3.0
Specific Rotation +43.0° ~ +50.0°
Heavy Metals (Pb) ≤10ppm
Loss on Drying ≤1.0%
Residue on Ignition ≤0.10%
Related Substances   
Cytosine ≤0.10%
α-Isomer ≤0.10%
Any Other Impurity ≤0.10%
Total Impurities ≤0.20%
Methanol ≤0.30%
Toluene ≤0.01%
Dichloromethane ≤0.01%
Acetone ≤0.50%
Assay 98.0%~102.0% (Calculated on dried base) 
Test Standard United States Pharmacopeia (USP) Standard
Usage Active Pharmaceutical Ingredient (API)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

1
2

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Gemcitabine Hydrochloride (CAS: 122111-03-9) with high quality API. 

Gemcitabine Hydrochloride (CAS: 122111-03-9) is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of DNA polymerase and is also incorporated in DNA strands resulting in termination of chain elongation and apoptosis. dFdCDP is an inhibitor of ribonucleotide reductase which results in depletion of deoxyribonucleotides needed for DNA synthesis. Gemcitabine metabolites have also been reported to inhibit cytidine triphosphate synthetase (CTP synthetase)2 and deoxycytidylate deaminase (dCMP deaminase)3. Topoisomerase 1 has also been shown to be a target for gemcitabine. 

Gemcitabine Hydrochloride (CAS: 122111-03-9) is a synthetic novel difluoro nucleoside drug that is anti-metabolic and antineoplastic. It is researched and developed by the Eli Lilly and Company and approved to be listed in South Africa, Sweden, the Netherlands, Australia and other countries in 1995. The United States Food and Drug Administration ( referred FDA) approved it as the first-line therapy for the clinical treatment of non-small cell lung cancer and pancreatic cancer. Gemcitabine hydrochloride, as a pro-drug, is a good substrate for the acidification of deoxygenation of thymine kinase phosphorus in the cell, and under the action of the enzyme, it can be converted into the following metabolites: gemcitabine mono-phosphate (dFdCMP), gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP), among which the latter two are the active products. 


Product detail pictures:

New Delivery for Pregabalin - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu detail pictures


Related Product Guide:

The purchaser fulfillment is our primary focus on. We uphold a consistent level of professionalism, high quality, credibility and service for New Delivery for Pregabalin - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu , The product will supply to all over the world, such as: Dubai, Hungary, Seattle, Profession, Devoting are always fundamental to our mission. We have always been in line with serving customers, creating value management objectives and adhering to the sincerity, dedication, persistent management idea.
  • We are really happy to find such a manufacturer that ensuring product quality at the same time the price is very cheap.
    5 Stars By Mignon from Turkmenistan - 2017.02.18 15:54
    The company account manager has a wealth of industry knowledge and experience, he could provide appropriate program according our needs and speak English fluently.
    5 Stars By Aaron from Costa rica - 2017.09.28 18:29
    Write your message here and send it to us