SODIUM SALICYLATE
Natrii salicylas
C7H5NaO3
Mr 160.1
[54-21-7]
DEFINITION
Sodium 2-hydroxybenzenecarboxylate.
Content: 99.0 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: white or almost white, crystalline powder or small, colourless crystals or shiny flakes.
Solubility: freely soluble in water, sparingly soluble in ethanol (96 per cent).
IDENTIFICATION
First identification: A, C.
Second identification: B, C.
A. Infrared absorption spectrophotometry (2.2.24).
Comparison: sodium salicylate CRS.
B. Solution S (see Tests) gives the reactions of salicylates (2.3.1).
C. It gives reaction (b) of sodium (2.3.1).
TESTS
Solution S. Dissolve 5.0 g in carbon dioxide-free water R prepared from distilled water R and dilute to 50 mL with the same solvent.
Appearance of solution. Solution S is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2,Method II).
Acidity. To 20 mL of solution S add 0.1 mL of phenol red solution R. The solution is yellow. Not more than 2.0 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to violet-red.
Chlorides (2.4.4): maximum 200 ppm.
To 5 mL of solution S add 5 mL of water R and 10 mL of dilute nitric acid R and filter. Dilute 10 mL of the filtrate to 15 mL with water R.
Sulfates (2.4.13): maximum 600 ppm.
Dilute 2.5 mL of solution S to 15 mL with distilled water R.
Loss on drying (2.2.32): maximum 0.5 per cent, determined on 1.00 g by drying in an oven at 105 °C.
ASSAY
Dissolve 0.130 g in 30 mL of anhydrous acetic acid R. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically (2.2.20).
1 mL of 0.1 M perchloric acid is equivalent to 16.01 mg of C7H5NaO3.
STORAGE
In an airtight container, protected from light.
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Post time: Apr-25-2024