OEM China 4-(4-Aminophenyl)morpholin-3-one - N-(4-Aminobenzoyl)-L-Glutamic Acid H-4-ABZ-Glu-OH CAS 4271-30-1 Folic Acid Intermediate – Ruifu

Manufacturer Supply; High Purity and Competitive Price
Chemical Name: N-(4-Aminobenzoyl)-L-glutamic acid
Synonyms: H-4-ABZ-Glu-OH
CAS: 4271-30-1
Intermediate of Folic Acid (CAS: 59-30-3)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. Commercial Supply N-(4-Aminobenzoyl)-L-glutamic acid ; H-4-ABZ-Glu-OH; CAS: 4271-30-1. It is the intermediate of Folic Acid (CAS: 59-30-3).

In the synthesis of Folic Acid, first N-(4-amino-benzoyl) -L-glutamic acid and 2,4, 5-triamino-6-hydroxypyrimidine sulfate and trichloroacetone as raw materials, in the presence of catalyst, maintain a certain pH value, through the cyclization reaction to prepare folic acid, and then through acid and alkali refining to get pure product.

The following description is taken from US Patent 2,956,057. 100 grams of 1,3,3-trichloroacetone are heated on a boiling water bath and 95 grams of bromine are added thereto in drops while being stirred and the stirring is continued for about 1 hour. The resulting reaction solution is distilled under reduced pressure. 115 grams of 1-bromo-1,3,3- trichloroacetone are obtained having a boiling point of 85° to 95°C/17 mm (Hg). For the preparation of the hydrate, 100 grams of water are added to 100 grams of 1bromo-1,3,3-trichloroacetone, which is agitated and cooled. A white scaly crystal of hydrate of 1-bromo-1,3,3-trichloroacetone is obtained (100 grams), having a melting point of 52° to 53°C. 8.9 grams of 2,4,5-triamino-6-hydroxypyrimidine hydrochloride and 8 grams of p-aminobenzoylglutamic acid are dissolved in 400 cc warm water, which is cooled at 35° to 27°C and adjusted to pH 4 by using 20% caustic soda solution. To this solution was simultaneously added dropwise a solution obtained by dissolving 13.4 grams of 1-bromo-1,3,3-trichloroacetone hydrate in 90 cc of 50% methanol and 24 grams of 35% aqueous sodium bisulfite solution over a period of approximately 2 hours. During this period, in order to maintain the pH value of the reaction solution at 4 to 5, 20% caustic soda solution is added from time to time. The precipitate, formed by stirring for 5 hours after dropping was finished, is filtered, and the filtrated precipitate is refined; 5.6 grams of pure pteroylglutamic acid is obtained.

Folic acid (folate) is a kind of B-vitamin which is mainly present in the liver and kidney. It has various kinds of pharmacological and physiological effects. It is involved in amino acid metabolism, purine and pyrimidine synthesis, and is also essential for hematopoiesis and red blood cell generation. In women pregnancy, folate can effectively prevent neural tube defects in the baby. It plays important role in fertility through contributing to spermatogenesis. It can also reduce the incidence of heart disease, stroke and cancer. Folate deficiency may lead to various kinds of diseases including glossitis, diarrhea, depression, confusion, anemia, and fetal neural tube defectsand brain defects (during pregnancy). Other symptoms may include fatigue, gray hair, mouth sores, poor growth, and swollen tongue.