OEM China Acotiamide Hydrochloride Trihydrate - Enalapril Maleate CAS 76095-16-4 API USP EP Standard High Purity – Ruifu

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OEM China Acotiamide Hydrochloride Trihydrate - Enalapril Maleate CAS 76095-16-4 API USP EP Standard High Purity – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Chemical Name: Enalapril Maleate
CAS: 76095-16-4
An angiotensin converting enzyme (ACE) inhibitor, used to treat high blood pressure, diabetes kidney disease, and chronic heart failure.
API High Quality, Commercial Production

Chemical Name	Enalapril Maleate
Synonyms	MK-421; 1-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-L-proline Maleate
CAS Number	76095-16-4
CAT Number	RF-API60
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C24H32N2O9
Molecular Weight	492.52
Brand	Ruifu Chemical

Item	Specifications
Appearance	White to Off-White Crystalline Powder
Specific Rotation	-48.0° ~ -51.0°
Loss on Drying	≤1.0%
Residue on Ignition	≤0.10%
Single Impurity	≤0.30%
Total Impurities	≤2.0%
Residual Solvents
Ethanol	≤5000ppm
Acetone	≤5000ppm
Dichloromethane	≤600ppm
Hexane	≤290ppm
Assay	98.5%~102.0% (on the dried basis)
Test Standard	USP Standard; EP Standard; Enterprise Standard
Usage	Active Pharmaceutical Ingredient (API)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Enalapril Maleate (CAS: 76095-16-4) is an angiotensin converting enzyme inhibitor (ACE), used to treat high blood pressure, diabetes kidney disease, and chronic heart failure. An antihypertensive. Inhibits the conversion of angiotensin I to angiotensin II. Orally active. Antihypertensive agent. Active in vivo and in vitro. Enalapril maleate (Vasotec), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Enalaprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin. Enalapril maleate salt is used as a long-acting ACE inhibitor and antihypertensive, used to study diabetic angiopathy in diabetic rats and inhibition of ACE in hog plasma (I50=1.2nM).

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