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OEM Factory for Valsartan - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu Featured Image
  • OEM Factory for Valsartan - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu

OEM Factory for Valsartan - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu

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OEM Factory for Valsartan - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu Detail:

Manufacturer Supply Irinotecan and Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3 
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4

Chemical Name Irinotecan Hydrochloride
Synonyms Camptothecin II; CPT-II
CAS Number 100286-90-6
CAT Number RF-API50
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C33H39ClN4O6
Molecular Weight 623.15
Melting Point 250-256℃ (dec.)
Storage Conditions Under Ambient Temperature
Brand Ruifu Chemical
Item Specifications
Appearance White or Off-White Powder
Solubility Soluble in water and methanol, slightly soluble in chloroform, ethanol
Identification IR The infrared absorption spectrum of the test sample should consistent with  that of the reference standard
Identification HPLC The retention time of major peak of the sample solution should correspond to that of the reference standard.
Identification Meets the requirements of the tests for Chloride Positive reaction 
Moisture (K.F) 7.0%~9.0% w/w
Residue on Ignition ≤0.10% 
Heavy Metals ≤20ppm
Irinotecan Hydrochloride Enantiomer ≤0.10% (HPLC)
7-Desethyl Irinotecan ≤0.15% 
Irinotecan Related Compound A ≤0.15% 
11-Ethyl Irinotecan ≤0.15% 
Camptothecin ≤0.15% 
Irinotecan Related Compound B ≤0.15% 
7-Ethylcanptothecin ≤0.15% 
7,11-Diethyl-10-Hydroxy Camptothecin ≤0.15% 
Any Unspecified Impurity ≤0.10% 
Total Impurities ≤0.50% 
Residual Solvents (GC)
Methanol ≤2000ppm
Acetone ≤2000ppm
Dichloromethane ≤500ppm
Peteoleum Ether: ≤100ppm
Ethyl Acetate ≤2000ppm
Benzene ≤2ppm
Bacterial Endotoxins ≤0.29 EU/mg Irinotecan
Microbial Limits Total Aerobic Microbial Count: <1000 cfu/g
Molds and Yeasts  <100 cfu/g
Purity / Analysis Method ≥99.0% (HPLC, on the anhydrous basis)
Test Standard United States Pharmacopeia (USP) Standard
Usage Active Pharmaceutical Ingredient (API)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

1

lrinotecan hydrochloride (CAS 100286-90-6), a semi-synthetic, water soluble derivative of the potent anticancer agent camptothecin, was launched in Japan for the treatment of lung, ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibition of topoisomerase I, a cellular enzyme that is involved in maintaining the topographic structure of DNA during the process of translation, transcription, and mitosis. lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38, which is 1000-fold more potent than the parent. Combination therapy of irinotecan with another widely used anticancer agent, cisplatin, has been reported to be superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal, breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin’s lymphoma.

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We always believe that one's character decides products' quality, the details decides products' quality ,with the REALISTIC,EFFICIENT AND INNOVATIVE team spirit for OEM Factory for Valsartan - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu , The product will supply to all over the world, such as: Lyon, Belgium, Seattle, We've got constantly insisted on the evolution of solutions, spent good funds and human resource in technological upgrading, and facilitate production improvement, meeting the wants of prospects from all countries and regions.
    • This manufacturer can keep improving and perfecting products and service, it is in line with the rules of market competition, a competitive company.
    5 Stars By Maria from Kenya - 2018.02.12 14:52
    Product variety is complete, good quality and inexpensive, the delivery is fast and transport is security, very good, we are happy to cooperate with a reputable company!
    5 Stars By Iris from South Africa - 2018.09.12 17:18
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