OEM Supply Ubenimex - Irinotecan Free Base CAS 97682-44-5 High Purity – Ruifu

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OEM Supply Ubenimex - Irinotecan Free Base CAS 97682-44-5 High Purity – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Supply Irinotecan and Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4

Chemical Name Irinotecan Free Base
CAS Number 97682-44-5
CAT Number RF-API51
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C33H38N4O6
Molecular Weight 586.68
Brand Ruifu Chemical
Item Specifications
Appearance Light Yellow Powder
Identification HPLC Retention time of sample corresponds to that of RS
Loss on Drying ≤5.0%
Single Max. Impurity ≤0.25%
Total Impurities ≤1.0%
Assay ≥99.0% (HPLC)
Test Standard Enterprise Standard
Usage API

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

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Irinotecan Free base is a camptothecin analog and topoisomerase I inhibitor. It may inhibit AChE. Irinotecan Free base is uesed to treat colon cancer, but it also moderates inhibition of dendritic cell differentiation and decreases the number of tumor vessels in glioma models. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex. The formation of this ternary complex interferes with the moving replication fork, which induces replication arrest and lethal double-stranded breaks in DNA. As a result, DNA damage is not efficiently repaired and apoptosis (programmed cell death) occurs. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively, and induces similar amounts of cleavable complexes in both in LoVo and HT-29 cells[2]. Irinotecan suppresses the proliferation of human umbilical vein endothelial cells (HUVEC), with an IC50 of 1.3 μM[3].In Vivo:Irinotecan (CPT-11, 5 mg/kg) significantly inhibits the growth of tumors by intratumoral injection daily for 5 days, on two consecutive weeks in rats, and such effects also occur via continuous intraperitoneal infusion by osmotic minipump into mice.


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With a positive and progressive attitude to customer's interest, our enterprise continually improves our products excellent to meet the wants of customers and further focuses on safety, reliability, environmental requirements, and innovation of OEM Supply Ubenimex - Irinotecan Free Base CAS 97682-44-5 High Purity – Ruifu , The product will supply to all over the world, such as: Japan, Pakistan, Angola, We have 48 provincial agencies in the country. We also have stable cooperation with several international trading companies. They place order with us and export products to other countries. We expect to cooperate with you to develop a larger market.
  • The sales manager has a good English level and skilled professional knowledge, we have a good communication. He is a warm and cheerful man, we have a pleasant cooperation and we became very good friends in private.
    5 Stars By Novia from Georgia - 2018.12.22 12:52
    We feel easy to cooperate with this company, the supplier is very responsible, thanks.There will be more in-depth cooperation.
    5 Stars By Victoria from Colombia - 2018.06.09 12:42
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