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OEM/ODM Factory Vildagliptin - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu Featured Image
  • OEM/ODM Factory Vildagliptin - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu

OEM/ODM Factory Vildagliptin - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu

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OEM/ODM Factory Vildagliptin - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu Detail:

Manufacturer Supply Irinotecan and Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3 
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4

Chemical Name Irinotecan Hydrochloride
Synonyms Camptothecin II; CPT-II
CAS Number 100286-90-6
CAT Number RF-API50
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C33H39ClN4O6
Molecular Weight 623.15
Melting Point 250-256℃ (dec.)
Storage Conditions Under Ambient Temperature
Brand Ruifu Chemical
Item Specifications
Appearance White or Off-White Powder
Solubility Soluble in water and methanol, slightly soluble in chloroform, ethanol
Identification IR The infrared absorption spectrum of the test sample should consistent with  that of the reference standard
Identification HPLC The retention time of major peak of the sample solution should correspond to that of the reference standard.
Identification Meets the requirements of the tests for Chloride Positive reaction 
Moisture (K.F) 7.0%~9.0% w/w
Residue on Ignition ≤0.10% 
Heavy Metals ≤20ppm
Irinotecan Hydrochloride Enantiomer ≤0.10% (HPLC)
7-Desethyl Irinotecan ≤0.15% 
Irinotecan Related Compound A ≤0.15% 
11-Ethyl Irinotecan ≤0.15% 
Camptothecin ≤0.15% 
Irinotecan Related Compound B ≤0.15% 
7-Ethylcanptothecin ≤0.15% 
7,11-Diethyl-10-Hydroxy Camptothecin ≤0.15% 
Any Unspecified Impurity ≤0.10% 
Total Impurities ≤0.50% 
Residual Solvents (GC)
Methanol ≤2000ppm
Acetone ≤2000ppm
Dichloromethane ≤500ppm
Peteoleum Ether: ≤100ppm
Ethyl Acetate ≤2000ppm
Benzene ≤2ppm
Bacterial Endotoxins ≤0.29 EU/mg Irinotecan
Microbial Limits Total Aerobic Microbial Count: <1000 cfu/g
Molds and Yeasts  <100 cfu/g
Purity / Analysis Method ≥99.0% (HPLC, on the anhydrous basis)
Test Standard United States Pharmacopeia (USP) Standard
Usage Active Pharmaceutical Ingredient (API)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

1

lrinotecan hydrochloride (CAS 100286-90-6), a semi-synthetic, water soluble derivative of the potent anticancer agent camptothecin, was launched in Japan for the treatment of lung, ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibition of topoisomerase I, a cellular enzyme that is involved in maintaining the topographic structure of DNA during the process of translation, transcription, and mitosis. lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38, which is 1000-fold more potent than the parent. Combination therapy of irinotecan with another widely used anticancer agent, cisplatin, has been reported to be superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal, breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin’s lymphoma.

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We attempt for excellence, support the customers", hopes to become the top cooperation team and dominator enterprise for staff, suppliers and shoppers, realizes worth share and continual marketing for OEM/ODM Factory Vildagliptin - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu , The product will supply to all over the world, such as: Italy, Albania, Plymouth, We can meet the various needs of customers at home and abroad. We welcome new and old customers to come to consult & negotiate with us. Your satisfaction is our motivation! Allow us to work together to write a brilliant new chapter!
    • The factory has advanced equipment, experienced staffs and good management level, so product quality had assurance, this cooperation is very relaxed and happy!
    5 Stars By Ryan from Czech republic - 2017.06.16 18:23
    It's really lucky to find such a professional and responsible manufacturer, the product quality is good and delivery is timely, very nice.
    5 Stars By Beulah from Mexico - 2017.03.28 12:22
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