One of Hottest for Ropivacaine HCl.H2O - Ambrisentan CAS 177036-94-1 Purity >99.0% (HPLC) API Factory High Purity – Ruifu

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One of Hottest for Ropivacaine HCl.H2O - Ambrisentan CAS 177036-94-1 Purity >99.0% (HPLC) API Factory High Purity – Ruifu Detail:

Commercial Supply Ambrisentan (CAS: 177036-94-1) Related Intermediates:
Ambrisentan CAS: 177036-94-1
Methyl 2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoate CAS: 178306-47-3
2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoic Acid CAS: 178306-51-9
(S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS: 178306-52-0
L-Proline Methyl Ester Hydrochlorid CAS: 2133-40-6
4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine CAS: 35144-22-0

Chemical Name	Ambrisentan
Synonyms	(S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-Methoxy-3,3-Diphenylpropionic Acid; (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-Methoxy-3,3-Diphenylpropanoic Acid
CAS Number	177036-94-1
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C22H22N2O4
Molecular Weight	378.43
Specific Rotation [α]D20	+170.0° to +176.0° (C=0.5, MeOH)
Melting Point	172.0~178.0℃(dec.)
Solubility	Very Soluble in Methanol; Soluble in Ethanol, Acetone; Insoluble in Water
Brand	Ruifu Chemical

Item	Specifications
Appearance	White or Off-White Powder
Identification	HPLC; NMR; LC-MS
Related Substances
Individual Impurity	≤0.50%
Total Impurities	<1.00%
Loss on Drying	≤0.50%
Residue on Ignition	≤0.20%
Heavy Metals	≤20ppm
Purity / Analysis Method	>99.0% (HPLC)
Test Standard	Enterprise Standard
Usage	Pharmaceutical Intermediates

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

Ambrisentan (CAS: 177036-94-1) is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors. In June of 2007, the FDA granted approvalof ambrisentan for once-daily treatment of PAH.

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