Popular Design for 1 2 3 4-Tetrahydro-1-phenylisoquinoline - Edaravone CAS 89-25-8 High Purity 1-Pheny-3-Methyl-5-Pyrazolone (PMP) – Ruifu

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Popular Design for 1 2 3 4-Tetrahydro-1-phenylisoquinoline - Edaravone CAS 89-25-8 High Purity 1-Pheny-3-Methyl-5-Pyrazolone (PMP) – Ruifu Detail:

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Name: Edaravone
Synonyms: 3-Methyl-1-phenyl-5-pyrazolone; MCI-186
CAS: 89-25-8
Edaravone is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.
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Name	Edaravone
Synonyms	3-Methyl-1-phenyl-5-pyrazolone; MCI-186
CAS Number	89-25-8
CAT Number	RF-PI237
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C10H10N2O
Molecular Weight	174.2
Brand	Ruifu Chemical

Item	Specifications
Appearance	Light Yellow Crystal or Powder
Purity	≥98.0%
Melting Point	127.0~130.0℃
Loss on Drying	≤0.50%
Residue on Ignition	≤0.50%
Heavy Metals	≤20ppm
Solubility	Soluble in 5% Hydrochloric Acid
Test Standard	Enterprise Standard
Usage	API; Pharmaceutical Intermediates

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Edaravone(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction. Edaravone is a radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.

Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.

Edaravone may be used: As a reagent for the detection of reducing carbohydrates by ESI/MALDI-MS. To improve the sensitivity of reducing mono- and oligo-saccharides for their subsequent determination using capillary zone electrophoresis. For the precolumn derivatization of the monosaccharide components of Salvia miltiorrhiza, liguspyragine hydrochloride, and glucose injection prior to their analysis by high performance liquid chromatography (HPLC).

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