PriceList for Deslorelin - Darunavir Ethanolate CAS 635728-49-3 Purity ≥99.0% API Factory Anti-HIV HIV Protease Inhibitor – Ruifu

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PriceList for Deslorelin - Darunavir Ethanolate CAS 635728-49-3 Purity ≥99.0% API Factory Anti-HIV HIV Protease Inhibitor – Ruifu Detail:

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Chemical Name	Darunavir Ethanolate
Synonyms	DRV; Prezista; TMC114 Ethanolate; UNII-33O78XF0BW; N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester compd. with ethanol
CAS Number	635728-49-3
CAT Number	RF-API69
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C29H43N3O8S
Molecular Weight	593.73
Brand	Ruifu Chemical

Item	Specifications
Appearance	White or Off-White Crystalline Powder
Identification IR	Corresponds to the Standard Spectrum
Specific Rotation	-0.5°~ +0.5°
Related Substances	(by HPLC)
Max Single Impurity	≤0.20%
Total Impurities	≤0.50%
Water (K.F)	≤1.0%
Residue on Ignition	≤0.10%
Heavy Metals	≤10ppm
Content of Ethanol	≤7.5% (GC)
Residual Solvents	Methanol ≤0.30%
Purity	≥99.0% (HPLC)
Test Standard	Enterprise Standard
Usage	Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral

Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Darunavir Ethanolate (Prezista) is an HIV protease inhibitor. Derivative of Darunavir, a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product. Unfortunately, DRV has low solubility in water and poor bioavailability, therefore it requires administration in relatively high doses in order to exhibit therapeutic efficacy. Darunavir is a broad-spectrum potent inhibitor active against HIV-1 clinical isolates with minimal cytotoxicity. Darunavir forms hydrogen bonds with the conserved main-chain atoms of Asp29 and Asp30 of the protease. These interactions are proposed to be critical for the potency of this compound against HIV isolates that are resistant to multiple protease inhibitors. In an in vitro study in MT-2 cells, the potency of darunavir is greater than that of saquinavir, amprenavir, nelfinavir, indinavir, lopinavir and ritonavir. Darunavir is primarily metabolized by the hepatic cytochrome P450 (CYP) enzymes, primarily CYP3A. The ‘boosting’ dose of ritonavir acts an an inhibitor of CYP3A, thereby increasing darunavir bioavailability. Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutati.

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