(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS 23357-47-3 Purity ≥98.0% e.e ≥99.0% Palonosetron Hydrochloride Intermediate Factory

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid (CAS: 23357-47-3) with high quality, used in synthesis of active pharmaceutical ingredient (API). It can be used in the synthesis of  Palonosetron Hydrochloride (CAS: 135729-62-3). Palonosetron Hydrochloride is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention.