(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem and Darifenacin hydrobromide Intermediate
Manufacturer Supply; High Purity and Competitive Price
Shanghai Ruifu Chemical Co., Ltd. Commercial Supply Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Intermediate of Panipenem (CAS 87726-17-8) and Darifenacin hydrobromide (CAS 133099-07-7)
| Chemical Name | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Synonyms | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride; (R)-(-)-3-Hydroxypyrrolidine-HCl |
| CAS Number | 104706-47-0 |
| CAT Number | RF-CC102 |
| Purity / Analysis Method | ≥98.0% (GC) |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C4H10ClNO |
| Molecular Weight | 123.58 |
| Melting Point | 107.0 ~ 111.0 °C |
| Solubility in Water | Almost Transparency |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Off-White to Pale Brown Crystalline Powder |
| Purity / Analysis Method | ≥99.7% (GC) |
| Chiral Purity | ≥99.7% e.e |
| Residue on Ignition | ≤0.50% |
| Specific Rotation [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Any Individual Impurity | ≤0.20% |
| Total impurities | ≤0.30% |
| Test Standard | Enterprise Standard |
| Usage | Pharmaceutical Intermediates; Chiral Compounds |
Analysis Method
Eqiupment: GC instrument (Shimadzu GC-2010)
Column: DB-17 Agilent 30mX0.53mmX1.0μm
Initial oven temperature: 80℃
Initial time 2.0min
Rate 15℃/min
Final oven temperature: 250℃
Final time 20min
Carrier gas Nitrogen
Mode Constant flow
Flow 5.0mL/min
Split ratio 10:1
Injector temperature: 250℃
Detector temperature: 300℃
Injection volume 1.0μL
Precautions to be taken before analysis:
1. Condition column at 240℃ for minimum 30minutes.
2. Wash the syringe and clean injector liner properly to remove the contaminants of earlier analysis.
3. Wash, dry and fill diluent in syringe wash vials.
Diluent preparation:
Prepare 2% w/v sodium hydroxide solution in water.
Standard preparation:
Weigh about 100mg of (R)-3-hydroxyprrolidine hydrochloride standard into a vial, add 1mL of diluent and dissolve.
Test preparation:
Weigh about 100mg of test sample into a vial, add 1mL of diluent and dissolve. Prepare in duplicate.
Procedure:
Inject blank (diluent), standard preparation and test preparation using above GC conditions. Disregard the peaks due to blank. The retention time of peak due to (R)-3-hydroxyprrolidine is about 5.0min.
Note:
Report the result as an average
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) with high quality, widely used in organic synthesis, synthesis of pharmaceutical intermediates and Active Pharmaceutical Ingredient (API) synthesis.
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) is an intermediate typically in the synthesis of Panipenem (CAS 87726-17-8) and Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents.
Route of Synthesis of (R)-3-Hydroxypyrrolidine hydrochloride
(R)-4-chloro-3-hydroxybutanitrile was reacted with trimethyl chlorosilane in dichloromethane solvent to obtain (R)-4-chloro-3-trimethylsiloxy butanitrile. (R)-4-chloro-3-trimethylsiloxyebutylamine was then hydrogenated on Pd/C catalyst.(R)-3-trimethylsiloxyepyrrolidine was obtained by sodium hydroxide ring closing treatment. Finally, the (R)-3-hydroxypyrrolidine hydrochloride product was obtained by concentrated hydrochloric acid treatment and the trimethylsilyl protective group was removed.
