Ramelteon Intermediate CAS 196597-78-1 Purity >98.5% (HPLC)

Short Description:

Name: 1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one

Synonyms: 6,7-Dihydro-1H-Indeno[5,4-b]furan-8(2H)-one

CAS: 196597-78-1

Purity: >98.5% (HPLC)

Appearance: White to Pale Yellow Solid Powder

Intermediate of Ramelteon (CAS: 196597-26-9)

High Quality, Commercial Production

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

196597-78-1 - Description:

Shanghai Ruifu Chemical is the leading supplier of 1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one (CAS: 196597-78-1) with high quality, mainly used as an intermediates of Ramelteon (CAS: 196597-26-9).
Ruifu Chemical has been supplying pharmaceutical intermediates and API (active pharmaceutical ingredient) more than 15 years, can provide worldwide delivery, competitive price, excellent service.
Purchase intermediates of Ramelteon, please e-mail: alvin@ruifuchem.com

Intermediates of Ramelteon:

Ramelteon (TAK-375)	CAS 196597-26-9
2,3-Dihydrobenzofuran	CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one	CAS 196597-78-1
Ramelteon Acrylonitrile	CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride	CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride	CAS 1053239-39-6

196597-78-1 - Chemical Properties:

Chemical Name	1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Synonyms	6,7-Dihydro-1H-Indeno[5,4-b]furan-8(2H)-one; Ramelteon Intermediate 1; Ramelteon I
Impurity	Ramelteon Impurity A
CAS Number	196597-78-1
Stock Status	In Stock, Production Capacity 20 Tons per Month
Molecular Formula	C11H10O2
Molecular Weight	174.20
Melting Point	133.0 to 137.0℃
Boiling Point	334.2±42.0℃
Density	1.288±0.06 g/cm3
Shelf Life	24 Months When Properly Stored
COA & MSDS	Available
Place of Origin	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

196597-78-1 - Specifications:

Item	Specifications
Appearance	White to Pale Yellow Solid Powder
Purity / Analysis Method	>98.5% (HPLC)
Melting Point	133.0 to 137.0℃
Water (by Karl Fischer)	<0.50%
Residue on Ignition	<0.10%
Total Impurities	<1.50%
1 H NMR Spectrum	Consistent With Structure
Test Standard	Enterprise Standard
Application	Intermediate of Ramelteon (CAS: 196597-26-9)

196597-78-1 - Package/Storage/Shipping:

Package: Bottle, aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Prevent direct sunlight; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.

196597-78-1 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

196597-78-1 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

196597-78-1 - Risk and Safety:

Hazard Class

IRRITANT

196597-78-1 - Application:

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one (CAS: 196597-78-1) is used as an intermediate of Ramelteon (CAS: 196597-26-9), the mother nucleus of synthesizing Ramelteon.
Ramelteon is the first in a new class of sleep agents that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABA receptors. Ramelteon does not show any appreciable binding to GABAA receptors, which are associated with anxiolytic, myorelaxant, and amnesic effects. Ramelteon can be used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse, and the withdrawal and rebound insomnia that is typical with GABA modulators is not present in ramelteon. Some clinicians also use ramelteon for the treatment of Delayed sleep phase syndrome. Treating insomnia (trouble falling asleep). It may also be used for other conditions as determined by your doctor. Ramelteon is a melatonin agonist. It works by acting on the melatonin receptors in the brain, which helps you fall asleep.