Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API High Quality

Short Description:

Chemical Name: Remdesivir (GS-5734)

CAS: 1809249-37-3

Appearance: White to Off-White Solid Powder

Assay: 98.0%~102.0%

Remdesivir for the treatment of COVID-19

API High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Manufacturer Commercial Supply Remdesivir and Related Intermediates with High Quality
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
Trimethylsilyl Cyanide CAS 7677-24-9
4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
Remdesivir N-2 Intermediate CAS 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1

Chemical Properties:

Chemical Name	Remdesivir
Synonyms	GS-5734; 2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
CAS Number	1809249-37-3
CAT Number	RF-API96
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C27H35N6O8P
Molecular Weight	602.58
Density	1.47±0.1 g/cm3
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White to Off-White Solid Powder
Identification A	IR: The infrared absorption spectrum of the product should be consistent with that of the reference substance
Identification B	HPLC Retention time similar to reference substance
Specific Rotation	-19.0° ~ -22.0°
Solubility	Solunle in Methanol, Sparingly Soluble in Ethanol, Slightly Soluble in Acetonitrile, Practically Insoluble in Water
Related Substances
Any Individual Impurity	≤0.10%
Total Impurities	≤1.0%
RD-3.1	≤0.10%
RD-C	≤0.10%
RD-D	≤0.10%
RD-E	≤0.10%
RP-Isomer	≤0.10%
Nitrophenol	≤0.10%
Residual Solvents
Methanol Dichloride	≤6000ppm
Acetone	≤5000ppm
Isopropyl Alcohol	≤5000ppm
Acetonitrile	≤410ppm
Dichloromethane	≤600ppm
Methyl tert Butyl Ether	≤5000ppm
Ethyl Acetate	≤5000ppm
Tetrahydrofuran	≤720ppm
n-Heptane	≤5000ppm
Assay	98.0%~102.0% (Calculated on the dried basis)
Total Aerobic Counts
Aerobic Bacteria	≤100cfu/g
Yeast and Mould	≤10cfu/g
E. Coil	Negative
Bacterial Endotoxin	≤1.0EU
Heavy Metals	≤20ppm
Test Standard	Enterprise Standard
Usage	API, COVID-19

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

FAQ:

Application:

Remdesivir (CAS 1809249-37-3), sold under the brand name Veklury, is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences. It is administered via injection into a vein. During the COVID-19 pandemic, remdesivir was approved or authorized for emergency use to treat COVID-19 in around 50 countries. Updated guidelines from the World Health Organization in November 2020 include a conditional recommendation against the use of Remdesivir for the treatment of COVID-19. Remdesivir was originally developed to treat hepatitis C, and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection treatment for COVID-19. The most common side effect in healthy volunteers is raised blood levels of liver enzymes (a sign of liver problems). The most common side effect in people with COVID-19 is nausea. Side effects may include liver inflammation and an infusion-related reaction with nausea, low blood pressure, and sweating. Remdesivir is a prodrug that is intended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase.