Remdesivir Intermediate CAS 1911578-98-7 2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate

Short Description:

Chemical Name: 2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate

CAS: 1911578-98-7

Appearance: White to Off-White Powder Purity: ≥98.0%

Intermediate of Remdesivir (CAS 1809249-37-3) COVID-19

High Quality, Commercial Production

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Description:

Manufacturer Commercial Supply Remdesivir and Related Intermediates with High Quality
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
Trimethylsilyl Cyanide CAS 7677-24-9
4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
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Chemical Properties:

Chemical Name	2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate
Synonyms	N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester; Remdesivir Intermediate; Remdesivir-001; Remdesivir Impurity 21
CAS Number	1911578-98-7
CAT Number	RF-PI303
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C21H27N2O7P
Molecular Weight	495.38
Density	1.2g/cm3
Melting Point	92.0~96.0℃(lit.)
Boiling Point	356.7℃ at 760 mmHg
Shipping Condition	Shipped Under Ambient Temperature
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White to Off-White Powder
Infrared Spectrum	Conforms to Structure
Purity	≥99.0%
Loss on Drying	≤0.50%
Single Impurity	≤0.50%
Total Impurities	≤1.0%
Heavy Metals	≤20ppm
Test Standard	Enterprise Standard
Usage	Intermediate of Remdesivir (CAS 1809249-37-3)

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

FAQ:

Application:

2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate (CAS 1911578-98-7) is an advanced key intermediate in the preparation of Remdesivir related analogs. Remdesivir is a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against SARS coronavirus, MERS coronavirus and, more recently, Covid-19. Remdesivir was mainly developed as a treatment for filovirus infections such as Ebola virus disease or Marburg virus. Subsequently, Remdesivir was found to show antiviral activity against other single-stranded RNA viruses such as respiratory syncytial virus, Nipah virus, Hendra virus, Junin virus, Lassa fever virus and the coronaviruses (including MERS and SARS viruses). Recently it is being studied as a promising medication for the treatment of COVID-19 (new SARS type virus). Remdesivir, developed by Gilead Sciences, is an adenosine prodrug that metabolizes into its active form GS-441524 which interferes with the action of viral RNA-dependent RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production.