(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2 Purity > 99.0%(GC) Afatinib Amprenavir Fosamprenavir Intermediate

Short Description:

Chemical Name: (S)-3-Hydroxytetrahydrofuran

CAS: 86087-23-2

Colerless Transparent to Light Yellwow Liquid

Purity: >99.0%(GC) Optical Purity: >99.0% (GC)

Intermediate of Afatinib, Amprenavir, Fosamprenavir

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

86087-23-2 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of (S)-(+)-3-Hydroxytetrahydrofuran (CAS: 86087-23-2) with high quality, intermediates of Afatinib, Amprenavir, Fosamprenavir, etc. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase (S)-(+)-3-Hydroxytetrahydrofuran, Please contact: alvin@ruifuchem.com

86087-23-2 - Chemical Properties:

Chemical Name	(S)-3-Hydroxytetrahydrofuran
Synonyms	(S)-(+)-3-Hydroxytetrahydrofuran; (S)-Tetrahydrofuran-3-ol; (S)-(+)-Tetrahydro-3-Furanol; Afatinib Intermediate B
CAS Number	86087-23-2
Stock Status	In Stock, Production Capacity 20 Tons per Month
Molecular Formula	C4H8O2
Molecular Weight	88.11
Boiling Point	80℃/15 mmHg(lit.)
Flash Point	79℃(174°F)
Density	1.103 g/mL at 25℃ (lit.)
Refractive Index n20/D	1.45 (lit.)
Water Solubility	Soluble in Water
Stability	Stable. Combustible. Incompatible with Strong Oxidizing Agents.
Shipping Condition	Shipped Under Ambient Temperature
COA & MSDS	Available
Place of Origin	Shanghai, China
Product Categories	Chiral Building Blocks; Pharmaceutical Intermediates
Brand	Ruifu Chemical

86087-23-2 - Specifications:

Item	Specifications	Results
Appearance	Colerless Transparent to Light Yellwow Liquid	Colerless Transparent Liquid
Identification	Retention Time of the Sample Should Match with the Retention Time of Reference Standard	Conforms
Purity / Analysis Method	>99.0% (GC)	99.81%
Specific Rotation [α]_D²⁰	+17.5° ± 2.5° (C=2 in MeOH)	+18.2°
Optical Purity	e.e >99.0% (GC)	99.90%
Water Content (K.F)	<0.50%	0.17%
(R)-(-)-3-Hydroxytetrahydrofuran	<0.15%	0.05%
Any Other Single Impurity	<0.40%	0.10%
Total impurities	<1.00%	0.19%
Test Standard	This product by inspection accords with the standard In-house

86087-23-2 - MOA:

MOA of (S)-(+)-3-Hydroxytetrahydrofuran (CAS: 86087-23-2)
Appearance: Observe the color of sample under daylight.
Identification (RT-GC): The retention time of the main peak in the chromatogram of the test solution corresponds to that of the reference standard solution, obtained as described in the E.E impurity.
Purity and Any Other Impurity
Analytical Conditions
Column: Capillary AT.OV-1701 (30m*0.32mm*0.50μm)
Detector Type: FID
Nitrogen: 50kPa
Air: 50kPa
Hydrogen: 50kPa
Oven Temperature: 60℃-1min 10℃/min 230℃-5min
Evaporation Temperature: 230℃
Detector Temperature: 260℃
Injection Volume: 0.25μl
Split Ratio: 20:1
Run Time: 20min
Test Solution
Transfer about 4ml of the sample in a 10.00ml volumetric flask, dissolve and dilute to volume with dichloromethane.
Test Procedure:
Inject test solution and record the chromatogram. Calculate the purity and any other impurity by area normalization method.
System suitability:
1) The tailing factor of main peak in the chromatogram is not more than 1.0;
2) The number of theoretical plates of main peak in the chromatogram is not less than 10,000.
E.E. Impurity (GC)
Analytical Conditions
Column: Capillary Chiral Column
Detector Type: FID
Nitrogen: 150kPa
Air: 50kPa
Hydrogen: 50kPa
Oven Temperature: 122℃
Evaporation Temperature: 185℃
Detector Temperature: 200℃
Injection Volume: 0.10μl
Split Ratio: 80:1
Run Time: 15min
Ref. Standard Solution
Transfer about 1ml of (R)-(-)-3-Hydroxytetrahydrofuran Ref. standard and 2.5ml of dichloromethane in a penicillin bottle, dissolve and shake up.
Test Solution:
Transfer about 2ml of sample in a 10.00ml volumetric flask, dissolve and dilute to volume with dichloromethane.
Test Procedure:
Inject test solution and record the chromatogram. Calculate the e.e impurity by area normalization method.
System suitability:
1) The resolution of two main peaks in the chromatogram is not less than 1.5;
2) The number of theoretical plates of main peak in the chromatogram is not less than 15,000.
Water Content
Weigh 1.0ml sample to be examined, test the water content by V10 Carle Fischer moisture apparatus.

86087-23-2 - ROS:

86087-23-2 - Package/Storage/Shipping:

Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Prevent direct sunlight; avoid open flames, high temperature, and flammable materials. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

86087-23-2 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

86087-23-2 - FAQ:

86087-23-2 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
UN IDs NA 1993 / PGIII
WGK Germany 3
HS Code 2932190090

86087-23-2 - Application:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-(+)-3-Hydroxytetrahydrofuran (CAS: 86087-23-2) with high quality, widely used in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (API).
(S)-(+)-3-Hydroxytetrahydrofuran is the main intermediate of Afatinib (CAS 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Amprenavir (CAS 161814-49-9) and Fosamprenavir (CAS 226700-79-4).
Afatinib (CAS 439081-18-2) is a potent, covalent/irreversible, and orally bioavailable dual (EGFR/ErbB) receptor tyrosine kinase (RTK) inhibitor with anticancer activity. Afatinib (CAS 439081-18-2) is a prescription medicine that can be taken orally for the treatment of non-small cell lung cancer (NSCLC) with atypical Epidermal Growth Factor Receptor (EFGR) agents.
Amprenavir (CAS 161814-49-9) is a HIV protease inhibitor used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.
Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavi.