Sitagliptin Triazole Hydrochloride CAS 762240-92-6 Purity >99.0% (HPLC) Factory High Quality

Short Description:

Name: Sitagliptin Triazole Hydrochloride

CAS: 762240-92-6

Purity: >99.0% (HPLC)

Appearance: White to Off-White Crystalline Powder

Intermediate of Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9) for the treatment of type II diabetes mellitus

High Quality, Commercial Production

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Product Detail

Product Tags

Description:

Supply Sitagliptin Phosphate Monohydrate Related Intermediates:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Intermediate CAS 486460-21-3

Chemical Properties:

Chemical Name	3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
Synonyms	Sitagliptin Triazole Hydrochloride; Sitagliptin Intermediate A
CAS Number	762240-92-6
CAT Number	RF-PI1193
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C6H7F3N4·HCl
Molecular Weight	228.60
Melting Point	236.0~246.0℃
Solubility	Soluble in Methanol
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White to Off-White Crystalline Powder
Identification by HPLC	The retention time of sample is concordant with reference standard
Identification by IR	Complies
Loss on Drying	<0.50%
Related Substances
Any Single Impurity	<0.50%
Total Impurities	<1.00%
Heavy Metals	<20ppm
Purity / Analysis Method	>99.0% (HPLC)
Test Standard	Enterprise Standard
Usage	Intermediate of Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9)

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

Advantages:

FAQ:

Application:

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride (CAS: 762240-92-6) is an intermediate of Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9), which is an orally-bioavailable selective DPP4 inhibitor that was discovered through the optimization of a class of β-aminoacid-derived DPP4 inhibitors. It lowers DPP4 activity in a sustained manner following once daily administration, preserves the circulating levels of intact GIP and GLP1 following meals in both acute and chronic studies and reduces blood glucose levels without significant increases in hypoglycaemia. Sitagliptin Phosphate (STG) is used to treat DM type 2 because it improves glycemic control by increasing the levels of active incretin hormones, GLP-1 (peptide-1) and GIP (glucose-dependent insulinotropic peptide). STG was approved by the FDA in 2006.