Special Design for (S)-3-Amino-3-phenylpropionic Acid - LCZ696 Intermediate CAS 1426129-50-1 Purity ≥98.0% (HPLC) e.e ≥99.0% (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate – Ruifu

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Special Design for (S)-3-Amino-3-phenylpropionic Acid - LCZ696 Intermediate CAS 1426129-50-1 Purity ≥98.0% (HPLC) e.e ≥99.0% (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Commercial Supply LCZ696 (CAS: 936623-90-4) Related Intermediates:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1′-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1′-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1′-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium salt) CAS: 1369773-39-6
AHU-377; Sacubitril CAS: 149709-62-6
LCZ696; Entresto; Sacubitril mixture with Valsartan CAS: 936623-90-4

Chemical Name	(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Synonyms	LCZ696 Intermediate
CAS Number	1426129-50-1
CAT Number	RF-PI169
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C20H25NO3
Molecular Weight	327.42
Brand	Ruifu Chemical

Item	Specifications
Appearance	White to Off-White Powder
Purity / Analysis Method	≥98.0% (HPLC)
Enantiomeric Excess	e.e: ≥99.0%
Moisture (K.F)	≤1.0%
Related Substances A	≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol
Related Substances B	≤1.0% (RRT=0.85) B=Triphenylphosphine oxide
Other Substances	≤1.0%
Total Impurities	≤2.0%
Test Standard	Enterprise Standard
Usage	Intermediate of LCZ696 (CAS: 936623-90-4) in the treatment of HFrEF

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

LCZ696 a drug developed by Novartis Pharmaceutical of the United States for the treatment of heart failure. Heart failure is a life-threatening disease. The patient’s heart cannot pump enough blood to supply the body, and appear the symptoms of dyspnea, fatigue and fluid retention slowly, then gradually increased, significantly affect the quality of life. LCZ696 is a dual-acting angiotensin-receptor enkephalinase inhibitor that has a unique mechanism that is thought to reduce the strain of failing hearts. LCZ696 can enhance the body’s natural defense against heart failure, as well as increase the level of natriuretic peptides and other endogenous vasoactive peptides, and inhibit the renin-angiotensin-aldosterone system (RAAS). LCZ696 has combined with Novartis’s Hypertension Medication (Diovan, generic name: valsartan) and the experimental drug AHU-377. AHU377 blocks the mechanism of the two peptides responsible for lowering blood pressure. Diovan improves vasodilatation and stimulates the body to excrete sodium and water. LCZ696 is an experimental drug developed for the treatment of patients with Heart Failure with reduced Ejection Fraction (HFrEF). LCZ696, composed of valsartan and sacubitril in a 1: 1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for the treatment of hypertension and heart failure.

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