Special Price for Noscapine Hydrochloride Hydrate - Cisatracurium Besylate CAS 96946-42-8 Assay 95.0%~102.0% API High Quality – Ruifu

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Special Price for Noscapine Hydrochloride Hydrate - Cisatracurium Besylate CAS 96946-42-8 Assay 95.0%~102.0% API High Quality – Ruifu Detail:

High Purity and Stable Quality
Chemical Name: Cisatracurium Besylate
CAS: 96946-42-8
Appearance: White or Almost White Powder, Odorless, Slightly Hygroscopic
Assay: 95.0%~102.0% (C65H82N2O18S2 on the dried basis)

Chemical Name	Cisatracurium Besylate
CAS Number	96946-42-8
CAT Number	RF-API13
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C53H72N2O12.2C6H5O3S
Molecular Weight	1243.49
Brand	Ruifu Chemical

Item	Specifications
Appearance	White or Almost White Powder, Odorless, Slightly Hygroscopic
Solubility	Freely soluble in dichloromethane, acetonitrile, slight soluble in water
Specific Rotation	-35°~-45° (C=10mg/ml, 0.1mg/ml benzene sulfonic acid)
Identification	Dissolve with dilute hydrochoric acid, dropwise dilute bismuth potassium iodide TS, yellow precipitations will be produced
Identification	1. HPLC ; 2. I.R
Assay	95.0~102.0% (C65H82N2O18S2 on the dried basis)
pH	3.5~5.0
Clarity & Color of the Solution	Should be Clear & Colorless
Loss on Drying	≤2.0%
Residual on Ignition	≤0.20%
Heavy Metals	≤20ppm
Trans-Trans Isomer	≤0.50%
Cis-Trans Isomer	≤0.50%
Mono-quaternaries	≤1.50%
Anyother Individual Impurity	≤1.50%
Total Impurities	≤5.0%
Optical Isomer SS-Isomer	≤1.50%
Optical Isomer RS- Isomer	≤1.00%
Sulfate	≤50ppm
Ethyl	≤0.50%
Acetone	≤0.50%
Methanol	≤0.3%
Dichloromethane	≤0.06%
Acetonitrile	≤0.041%
Methylbenzene	≤0.089%
Residual Solvents Acetonitrile	≤410ppm
Test Standard	Chinese Pharmacopoeia (CP)
Usage	Active Pharmaceutical Ingredient (API)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Cisatracurium besylate is the benzene sulfonate salt form of atracurium. It is a kind of artificially synthetic non-depolarizing muscle relaxants with its role similar as tubocurarine. It has an onset time of 1 minute and duration time of 15 minutes. The treatment dose does not affect the heart, liver and kidney function. It also has no accumulation property. It also can induce the release of histamine when used at large doses. For muscle relaxation or breathing control required in surgery, compared with current clinical major muscle-relaxing anesthetic drugs, cisatracurium besylate is not metabolized through liver or kidney, and has cardiovascular stability; its effect of muscle relaxation is 3 times as strong as atracurium without any cardiovascular side effects. Cisatracurium besylate is mainly applied to general anesthesia, and can be widely used in intubation, treating liver and kidney dysfunction, used in cardiovascular surgery and elderly and pediatric patients. Compared with atracurium, this product has no dose-dependent adverse effects of histamine release; however, the disadvantage is that patients with liver and kidney dysfunction should administrate with caution. Since 1996 for the first time when this drug has entered into market in UK, foreign countries have gradually applied it to replace vecuronium and atracurium as the mainstream of clinical muscle relaxants.

The mechanism of action of cisatracurium besylate is similar with that of tubocurarine chloride; but this product is a kind of non-depolarizing muscle relaxant drugs which is mainly used for blocking the transmission of nerve impulses, boost muscle relaxation and can release histamine; but it has a lower effect than tubocurarine alkaline; it is characterized by a rapid onset and a high muscle relaxant effect.

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